Effects of Aerobic Exercise Intensity on Affective States and Brain Derived Neurotropic Factor in Patients With Depression
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- Change in serum brain derived neurotropic factor (BDNF)
研究概览
简要总结
Acute aerobic exercise improves affective stats in patients with mental illnesses. Brain derived neurotropic factor (BDNF) may be a biological mechanism that contributes to the affective benefits. The magnitude of the increase of serum BDNF might be exercise intensity dependent, but no study has compared low high-aerobic-intensity training at 90-95 % of the maximal heart rate (HRmax) with long-slow-distance training at 70 % of the HRmax in patients with depression.
The aim of this study is to compare changes in serum BDNF levels after high-aerobic-intensity training and long-slow-distance training in a intra-individual design in patients suffering from depression. The results will give indications of a possible difference in BDNF response between aerobic intensities and may be uses as pilot data for calculating sample size.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Moderate or severe depression (ICD10: F32-F33)
排除标准
- •Bipolar disorder.
研究组 & 干预措施
Exercise
Acute High aerobic intensity training (HIT) and long slow distance training (LSD)
干预措施: High aerobic intensity training (HIT) (Behavioral)
Exercise
Acute High aerobic intensity training (HIT) and long slow distance training (LSD)
干预措施: Long slow distance training (LSD) (Behavioral)
结局指标
主要结局
Change in serum brain derived neurotropic factor (BDNF)
时间窗: 15 minutes before exercise to 5> minutes after exercise.
To measure serum BDNF levels, blood samples will be taken before and after each workout session.
次要结局
- Change in affective symptoms(15 minutes before exercise to 15> minutes after exercise.)
- Change in state of anxiety.(15 minutes before exercise and 15> minutes after exercise.)
- Change in subjective exercise experience(15 minutes before exercise to 15> minutes after exercise.)
- Maximal oxygen uptake(Baseline)
- Maximal Heart rate(Baseline)