Treatment Effects From Aerobic Endurance Training and Maximal Strength Training in Patients Suffering From Schizophrenia

Not Applicable

Completed

• Conditions: Schizophrenia; Cardiovascular Disease
• Interventions: Other: Maximal strength training; Other: Aerobic high-intensity interval training (AIT); Other: Computer game training (CG)

• Registration Number: NCT00286299
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

This study investigates treatment effects from aerobic endurance training, maximal strength training and computer game on aerobic capacity, work efficiency and psychiatric symptoms in patients suffering from schizophrenia. The study is a controlled trial. The aim is to describe the population in respect to aerobic capacity and muscular strength. Low aerobic capacity and muscular strength are important risk factors for cardiovascular disease (CVD). The study also aim to evaluate physical and psychiatric effects from physical training. Effects from participation in physical training or computer game on symptoms, depression and quality of life will be investigated. Data will be collected between October 2005 and August 2007.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-10
• Study First Submitted: 2006-02-02
• Study First Submitted QC: 2006-02-02
• Study First Posted: 2006-02-03
• Primary Completion: 2008-07
• Study Completion: 2008-07
• Status Verified: 2017-03
• Last Update Submitted: 2017-03-28
• Last Update Posted: 2017-03-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 33

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Maximal strength training (MST)	Maximal strength training	MST is performed in a leg press machine. The weight is lowered in a controlled manner in the eccentric phase until the patient reached 90 degrees in the knee joint. Then the patients has a short stop (\~0.5 second) before the weight is moved as rapidly as possible to complete extension. The training volume is 4 sets of 4RM (i.e. 85-90 % 1RM). The training load is increased with 2.5-5 kg each time patients managed to perform 4 sets with the determined load or each training session.
Aerobic interval training (AIT)	Aerobic high-intensity interval training (AIT)	AIT is 4x4 minutes interval training on a treadmill at 85 to 95 % HRpeak interspersed with 3 min of active resting periods at a work load corresponding to 70 % HRpeak between each interval. Patients performed the intervals walking or running with a minimum of 5 % inclination.
Computer game training (CG)	Computer game training (CG)	36 minutes playing supervised computer games, Tetris, Xbox

Primary Outcome Measures

Name	Time	Method
peak aerobic capacity (VO2peak)	Pre- and Posttest

Secondary Outcome Measures

Name	Time	Method
The 36-item short form (SF-36)	Pre- and Posttest
Fasting blood samples, systolic and diastolic blood pressure.	Pre- and posttest
Positive and Negative Syndrome Scale (PANSS)	Pre- and Posttest
Calgary Depression Scale for Schizophrenia (CDSS)	Pre- and Posttest
60 Watt walking efficiency, Net efficiency	Pre- and Posttest
Maximal strength, measured as one repetition maximum (1RM) in a incline leg press machine (Technogym)	Pre- and Post test

Trial Locations

Locations (1)

St. Olavs Hospital, Department of Psychiatry; 🇳🇴 Trondheim, Norway