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临床试验/NCT02664727
NCT02664727已完成不适用

Effects of Acute Exercise on Psychological, Physiological, Biochemical and Alcohol-related Parameters in Individuals With Alcohol Use Disorders

University of Thessaly0 个研究点目标入组 13 人开始时间: 2014年1月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
13
主要终点
Changes in Urge to drink score

研究概览

简要总结

The purpose of this research is to examine the effects of exercise of different intensities on psychological, physiological, biochemical, physiological and alcohol-related parameters in individuals with alcohol use disorders (heavy drinkers and alcoholic patients) in order to investigate possible biochemical mechanisms by which exercise may be a healthy alternative to alcohol abuse. For that purpose, a control group of individuals that do not exceed the limits for moderate alcohol use will be included.

详细描述

The mechanism of incentives that lead people to unhealthy habits such as excessive alcohol consumption is not only social, personal, and psychological, but also associated with neurochemical and neurobiological mechanisms.

Several programs have been developed to stop excessive drinking, but the success rates are small, while the relapse rates are very high, reaching up to 90%. Although there is some evidence for the beneficial effects of exercise on alcohol use disorders (AUDs), research is limited. The present study investigates whether exercise could be a safe adjunct therapy for alcohol abuse cessation, and the possible mechanisms involved.

One of the basic assumptions is that the appropriate form of exercise in individuals with AUDs will contribute to the secretion of beta-endorphin, which in combination with psychological pleasure, vitality, change of mood, reduced stress, increased confidence, and the shift of attention will help people to follow healthy lifestyles and abhor alcohol.

The research project is divided in three phases. In the first phase, (current study) the effect of acute exercise in critical psychological, physiological, biochemical and alcohol-related parameters associated with excessive alcohol consumption will be examined. In the second phase, a long-term exercise program in conjunction with psychological support strategies aimed at alcohol abuse cessation will be developed, implemented and evaluated. Finally, in the third phase, based on the results of the previous phases, awareness programs in adolescent and adult populations will be designed and implemented as well as the dissemination of results and evaluation of the project will take place.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Confirmed alcohol addiction according to Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria in the past, after detoxification phase, lack of dependence on other substances
  • Alcohol Use Disorders Identification Test (AUDIT) score>20

排除标准

  • Medical conditions or medication use that would preclude participation in aerobic exercise
  • For heavy drinkers:
  • Inclusion Criteria:
  • Men drinking >14 drinks/week or >4 drinks/occasion; Women drinking >7 drinks/week or >4 drinks/occasion (1 drink = 14 grams of pure alcohol; definition of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) for drinking at low risk for developing an AUD; NIAAA, 2014)
  • Individuals drinking 5 or more drinks on the same occasion on each of 5 or more days in the past 30 days (1 drink = 14 grams of pure alcohol; definition of the Substance Abuse and Mental Health Services Administration for heavy drinking; NIAAA, 2014)
  • AUDIT score>8
  • Exclusion Criteria:
  • Medical conditions or medication use that would preclude participation in aerobic exercise
  • For healthy controls:
  • Inclusion Criteria:
  • Men drinking <14 drinks/week or <4 drinks/occasion; Women drinking <7 drinks/week or <4 drinks/occasion (1 drink = 14 grams of pure alcohol; definition of the NIAAA for drinking at low risk for developing an AUD; NIAAA, 2014)
  • Individuals drinking <5 drinks on the same occasion on each of 5 or more days in the past 30 days (1 drink = 14 grams of pure alcohol; definition of the Substance Abuse and Mental Health Services Administration for heavy drinking; NIAAA, 2014)
  • AUDIT score<8
  • Exclusion Criteria:
  • Medical conditions or medication use that would preclude participation in aerobic exercise

结局指标

主要结局

Changes in Urge to drink score

时间窗: Before (0 min) and after exercise trial (30 min)

According to questionnaire

Changes in Beta-endorphin levels

时间窗: Before (0 min) and after exercise trial (30 min)

Measured by radioimmunoassay (RIA)

Changes in Cortisol levels

时间窗: Before (0 min) and after exercise trial (30 min)

Measured by radioimmunoassay (RIA)

Changes in Adrenocorticotrophic hormone (ACTH) levels

时间窗: Before (0 min) and after exercise trial (30 min)

Measured by radioimmunoassay (RIA)

Changes in Catecholamines (epinephrine, norepinephrine, dopamine) levels

时间窗: Before (0 min) and after exercise trial (30 min)

Measured by radioimmunoassay (RIA)

Changes in C-reactive protein (CRP) levels

时间窗: Before (0 min) and after exercise trial (30 min)

Semi-quantitative estimation with CRP Latex test kit

Changes in Complete blood count values

时间窗: Before (0 min) and after exercise trial (30 min)

Autoanalyzer

Changes in Lactic acid levels

时间窗: Before (0 min) and after exercise trial (30 min)

Measured using photometry

Changes in Erythrocyte sedimentation rate (ESR) values

时间窗: Before (0 min) and after exercise trial (30 min)

Wintrobe Method

Changes in γ-Glutamyltransferase (GGT) levels

时间窗: Before (0 min) and after exercise trial (30 min)

Measured with commercial kit

Changes in Aspartate Aminotransferase (AST) levels

时间窗: Before (0 min) and after exercise trial (30 min)

Measured with commercial kit

Changes in Alanine Aminotransferase (ALT) levels

时间窗: Before (0 min) and after exercise trial (30 min)

Measured with commercial kit

次要结局

  • Sit and reach flexibility test for the hamstrings muscles and lower back(Before trial (baseline))
  • Grip strength(Before trial (baseline))
  • Number of push-ups performed in one minute(Before trial (baseline))
  • Number of sit-ups performed until exhaustion(Before trial (baseline))

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Athanasios Z. Jamurtas

Dr

University of Thessaly

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