Effect of Postextubation High-Flow Nasal Cannula vs Noninvasive Ventilation on Reintubation and Postextubation Respiratory Failure in Patients With Hypercapnic COPD，a Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Rate of reintubation
研究概览
简要总结
To test if high-flow conditioned oxygen therapy is noninferior to NIV for preventing postextubation respiratory failure and reintubation in patients with hypercapnic COPD, investigators plan to conduct the participants level, 1:1 randomized trial at the respiratory ICU. Participants were randomized to undergo either high-flow conditioned oxygen therapy or noninvasive mechanical ventilation after extubation. Primary outcomes were reintubation and postextubation respiratory failure within 72 hours. Secondary outcomes included length of RICU stay after extubation and mortality; partial pressure of arterial carbon dioxide.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of AECOPD
- •Extubation must be performed after 48 hours of invasive ventilation
- •Must be treated sequentially with HFNC or NIV after extubation
- •PaCO2≥50mmHg when extubation
- •Positive End Expiratory Pressure (PEEP) ≤8cmH2O (1cmH2O=0.098 kPa) when extubation
排除标准
- •Do-not-intubate
- •Tracheostomies
- •Accidental extubation
- •Self-extubation
研究组 & 干预措施
High-Flow Nasal Cannula
High-flow oxygen was applied immediately after extubation through specific nasal cannula.
干预措施: High-FlowNasal Cannula (Device)
Noninvasive Ventilation
Noninvasive Ventilation was applied immediately after extubation.
干预措施: Noninvasive Ventilation (Device)
结局指标
主要结局
Rate of reintubation
时间窗: Within 72 hours after extubation
The proportion of patients requiring reintubation within 72 hours after extubation
次要结局
- Mortality(Within 28 days after extubation)
- RICU length of stay after extubation(From date of extubation until the date of discharging from the RICU up to 28 days)
- Partial pressure of arterial carbon dioxide(Within 24 hours before extubation and within 72 hours after extubation)