Effect of a propolis tablet on the saliva and the amount of adolescent dental plaque microbes comparing with the use of another tablet without propolis

Phase 2

• Conditions: Propole; Dental caries; Dental Plaque

• Registration Number: RBR-8xm896
• Lead Sponsor: niversidade Federal do Rio de Janeiro

Brief Summary

Although propolis did not enhance the properties of XT, further studies testing different protocols and follow-up are necessary; XT controlled Streptococcus spp. in biofilms, which demonstrate its potential for clinical application.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-11-22
• Study Completion: 2020-03-31
• Results First Posted: 2020-11-24
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Data analysis completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Individuals aged 10-19 years; both genders; individuals without cavitary caries lesions; healthy individuals without any systemic diseases.

Exclusion Criteria

Individuals intolerant to some component of the propolis-containing tablet; subjects undergoing antimicrobial treatment during the course of the study or for a period of 30 days prior to the study; individuals who used products containing xylitol up to 30 days before the start of study or during the course of the study; individuals who used products containing propolis up to 30 days before the start of the study or during the course of the study; individuals with orthodontic appliances; individuals who are using oral mouthwashes during the period of study; individuals with a history of intraoral surgery within the last 6 months; individuals who are making use of products rich in polyphenols: coffee, mate, acai, in the previous period (30 days) and during the research; individuals who consume alcohol.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effect of xylitol tablets with and without propolis on the total microorganism count of adolescents biofilm using the scattering technique, considering the number of CFU/mg of biofilm.;Effect of xylitol tablets with and without propolis on the total microorganism count of adolescents saliva using the scattering technique.

Secondary Outcome Measures

Name	Time	Method
Effect of xylitol tablets with and without propolis on the concentration of soluble and insoluble extracellular polysaccharides of the biofilm of adolescents by means of the phenol-sulfuric method, based on the quantitative carbohydrate.;Acceptability of tablets for the appearance, flavor, aroma and texture of the tablets, by adolescents, by means of a questionnaire with a scale of 9 points.