Efficacy of etomidate versus propofol on seizure duration and hemodynamics in patients undergoing modified ECT- a randomised cross over study

This study is a randomised, double blind cross over study to compare the effectiveness of two different drugs - etomidate 0.2 mg/kg and propofol 1mg/kg - in terms of seizure duration and hemodynamics in patients undergoing modified electroconvulsive therapy. Either of the drug  depending on the study group, will be use as an anaesthetic agent of induction before the application of electrical stimulus in a total of 80 patients, divided into groups of 40 each and suffering from a range of mental disorders according to ICD 11. This study will be conducted in the department of Anaesthesia at a tertiary care centre in Nagpur.

The primary outcome measure will be the seizure duration measured by a stopwatch and hemodynamic changes - heart rate, systolic and diastolic blood pressure, mean arterial pressure, oxygen saturation and end tidal carbon dioxide levels by a multipurpose monitor

The secondary outcome will be measured in terms of the side effects produced by either of the drugs- pain on injection measured by the VAS scale, nausea, vomiting, postictal agitation , memory deficits measured by the MOCA and MMSE scales .