on-coding RNAs in neurogenic and neuropathic pain mechanisms and their application for risk assessment, patient stratification andpersonalised pain medicine

Recruiting

• Conditions: complex regional pain syndrome(CRPS); ICD 10 M89.0diabetic neuropathies (dPNP),ICD 10 G63.2nerve lesions (NL); ICD 10 G58.9; M89.0; G63.2; G58.9; Algoneurodystrophy; Diabetic polyneuropathy; Mononeuropathy, unspecified

• Registration Number: DRKS00008964
• Lead Sponsor: European Comission, Directorate - General for Research and Innovationl

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-08-05
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 1375

Inclusion Criteria

Patients have to suffer from the diseases of interest. Therefore, patients have to meet minimum diagnostic criteria for
CRPS, PNP, nerve lesions, headaches

Exclusion Criteria

patients suffering from tumors, acute infection or autoimmune diseases; pregnancy / lactation.
Other diseases are registered; but will not prevent patients from participating in the study. This is also applicable for affective disorders. Control subject shall not suffer from any pain disorder, including CRPS, PNP, headaches, as well as traumatic nerve lesions.
Patients with pregnancy, breast feeding period or with doubts about compliance will be not included.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary endpoint is to explore the role of ncRNA in chronic pain. Patients data will be explored, the results will be translated into rodent pain models and then backtranslated (confirmed) into patients.