Exploring the Genetics of Neuropathic Pain

Recruiting

• Conditions: Neuropathic Pain; Genetic Predisposition; Polyneuropathies
• Interventions: Genetic: Nerve conduction Studies

• Registration Number: NCT03862365
• Lead Sponsor: Oslo University Hospital

Brief Summary

In the present study the investigators will search for new genetic variants relevant for the development of neuropathic pain.

Detailed Description

Neuropathic pain is defined as "pain caused by a lesion or disease of the somatosensory nervous system". Neuropathic pain is a huge health problem worldwide, with an estimated prevalence of 7-8 % in the general population. In the present study the investigators will search for new genetic variants relevant for the development of this type of pain.

Peripheral nerve lesions only progress to neuropathic pain in some patients, yet is not completely understood why or how. Genetic studies of patients with rare neuropathic disorders have been important for elucidating novel molecular mechanisms of neuropathic pain, and new drugs for neuropathic pain are now being developed based on these findings. By using genetic association studies, one may identify new genetic variants which may help to identify key molecular mechanisms for a larger group of patients with neuropathic pain.

This project will use existing population-based cohorts, as well as establish a specific registry and biobank for patients with neuropathy in order to address these specific needs. This will allow the investigators to identify a large number of individuals with probable neuropathic pain and individuals with pain-free peripheral neuropathy (disease controls). International collaboration will contribute to study a large group of patients, which will be important in order to reach the project's goals. The results from the project are expected to increase current knowledge on the mechanisms of neuropathic pain, opening up new opportunities for innovative and improved treatments.

Dissemination of results will be organized in close collaboration with patient representatives, and will be done regularly throughout the course of the project. The will focus both on internal dissemination to the participating hospitals, and external dissemination through participation in conferences, submissions to scientific journals and by publishing patient-friendly information booklets and proactively informing media outlets and patient organizations.

Study Timeline

• Study Start: 2018-08-01
• Study First Submitted: 2018-12-11
• Study First Submitted QC: 2019-03-01
• Study First Posted: 2019-03-05
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-06
• Last Update Posted: 2023-11-07
• Primary Completion: 2027-01-01
• Study Completion: 2027-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 5000

Inclusion Criteria

1. The patient is between 18 and 70 years old.
2. The patient has consented.
3. The patient is referred for evaluation of possible distal symmetric polyneuropathy (DSPN).
4. The patient has filled out the questionnaires.

Exclusion Criteria

1. The patient is too sick to participate (eg. bedridden, fever).
2. The patient is unable to consent (eg. dementia, speech problems, psychiatric disorder).
3. Inflammatory acute polyneuropathy.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Diabetic polyneuropathy with pain	Nerve conduction Studies	Clinical and diagnostic test evaluation for the establishment of diabetic polyneuropathy with pain.
Polyneuropathy without pain	Nerve conduction Studies	Clinical and diagnostic test evaluation for the establishment of polyneuropathy without pain.
Polyneuropathy with pain	Nerve conduction Studies	Clinical and diagnostic test evaluation for the establishment of polyneuropathy with pain.
Carpal tunnel syndrome without pain	Nerve conduction Studies	Clinical and diagnostic test evaluation for the establishment of carpal tunnel syndrome without pain.
Diabetic polyneuropathy without pain	Nerve conduction Studies	Clinical and diagnostic test evaluation for the establishment of diabetic polyneuropathy without pain.
Carpal tunnel syndrome with pain	Nerve conduction Studies	Clinical and diagnostic test evaluation for the establishment of carpal tunnel syndrome with pain.

Primary Outcome Measures

Name	Time	Method
Phenotype; subgroup analysis of patients with neuropathic pain based on grading of pain	Baseline	Patients with neuropathic pain will be further subdivided in groups based on pain reports. Pain will be graded using validated questionnaires. The "Brief Pain Inventory-BPI" (Cleeland et al, 1994) questionnaire will be used as primary resource for pain grading, on a scale from 0 to 10 (0: no pain, 1-3: mild pain, 4-10: strong pain).
Genetic variants associated with neuropathic pain.	Baseline	Relevant genotypes will be found using genome-wide association study (GWAS) methodology, ie. with no assumptions regarding which genetic variants that may be relevant (no hypotheses regarding specific variants). This is going to be conducted by using array genotyping (SNPs) in order to identify genetic variants that might be associated with neuropathic pain. Genetic variants will be defined and named according to standard practice, without any room for local or study specific adaptations.
Phenotype; neuropathic pain yes/no	Baseline	Patients will be divided in two groups; neuropathy With pain (= neuropathic pain) and neuropathy without pain. For definition of neuropathic pain, the Neupsig guidelines (Finnerup et al, Pain 2016) will be used.It is estimated that about 600 patients will be included yearly for this purpose

Trial Locations

Locations (5)

Helse Stavanger HF; 🇳🇴 Stavanger, Norway

Haukeland University Hospital; 🇳🇴 Bergen, Norway

Oslo University Hospital; 🇳🇴 Oslo, Norway

University Hospital of North Norway; 🇳🇴 Tromsø, Norway

St. Olavs Hospital; 🇳🇴 Trondheim, Norway