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临床试验/NCT04527172
NCT04527172已完成不适用

Neuromuscular Ultrasonography Utility for Detection of Peripheral Neuropathy in Systemic Lupus Erythematosus

Assiut University1 个研究点 分布在 1 个国家目标入组 55 人开始时间: 2018年5月20日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
55
试验地点
1
主要终点
evaluate the rule of NMUS in detection of peripheral neuropathy in SLE patient

研究概览

简要总结

This study aims to evaluate the rule of NMUS in detection of peripheral neuropathy in SLE patient and to correlate it to traditional neurophysiological studies, clinical signs and activity of SLE.

详细描述

The frequency of SLE peripheral neuropathy documented by electrophysiology has been estimated to be approximately 30%.

The term peripheral neuropathies include symmetric polyneuropathy, single and multiple mononeuropathy, and radiculopathy.

There has been increasing interest in using ultrasonography (US) to aid peripheral neuropathy diagnosis and studies have shown good correlation with other imaging modalities. US is a non-invasive and inexpensive imaging device that has become widely available as a diagnostic tool at many fields.

so systemic lupus patients were enrolled in the study , performed nerve conduction study and neuromuscular ultrasound for bil. median, ulnar, peroneal, tibial and sural nerves , on statistics the cross sections were compared in neurophusiologically affected and non affected nerves, also the sensitivity and specifity of NMUS in comparison to the traditional NCS was calculated

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Cross Sectional

入排标准

年龄范围
17 Years 至 —(Child, Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • All adult SLE patients who was admitted to Rheumatology & Rehabilitation department of Assuit university hospital during time frame of study.
  • apparently healthy subjects with normal electrophysiological study
  • verbal consent, free and informed

排除标准

  • • Other causes of peripheral neuropathy:
  • Purely degenerative
  • Drug induced

结局指标

主要结局

evaluate the rule of NMUS in detection of peripheral neuropathy in SLE patient

时间窗: 6months

Measuring sensitivity and specificity of neuromuscular ultrasound in comparison to nerve conduction study

Describing the patterns of peripheral nerve affection in SLE patient

时间窗: 6months

Evaluating different studied nerves clinically, electrophyiologically and by neuromuscular ultrasonography

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Amira M elSonbaty

Principal Investigator

Assiut University

研究点 (1)

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