Effect of Remote Ischemic Perconditioning on Acute Kidney Injury in Adult Valve Replace
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Rheumatic Disease of Heart Valve
- Sponsor
- Central South University
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- Renal function
- Last Updated
- 13 years ago
Overview
Brief Summary
The purpose of this study is to determine whether Remote Ischemic Perconditioning is effective on Acute kidney injury in adult valve replacement.
Detailed Description
Methods: Patients meeting the requirement will be randomized into 2 groups: the treatment group consisted of three 5-minute cycles left lower limb ischemia, induced by inflating a blood pressure cuff on the lower limb to 600 mmHg with an intervening 5 minutes of reperfusion, during which time the cuff was deflate; the control group consisted of placing an uninflated cuff on the left lower limb for 30 minutes. The postconditioning protocol was applied after the aortic cross-clamping. The clinical data of inotropes requirement, drainage, ventilation and intensive care time will be recorded. Venous blood samples will be taken perioperatively for detecting concentration of troponin I (cTnI), Myocardial enzyme, Renal function, Cystatin c, and High-sensitivity c-reactive protein(HS-CRP).
Investigators
Luo Wanjun
Director
Central South University
Eligibility Criteria
Inclusion Criteria
- •rheumatic heart valve disease requiring selective aortic or double valve(aortic and mitral valve) replacement
Exclusion Criteria
- •infective endocarditis congenital valve disease previous cardiac surgery complicated with rereplace valve
- •Renal dysfunction
- •coronary artery disease
- •hypertension
- •peripheral vascular disease affecting the lower limb free of arteriovenous fistula
- •receiving aspirin, corticosteroids, angiotensin-converting enzyme inhibitors or statin perioperatively
Outcomes
Primary Outcomes
Renal function
Time Frame: within the first 48h after cardiac surgery
Secondary Outcomes
- concentration of troponin I (cTnI)(within 48h after cardiac surgery)
- Myocardial enzyme(within 48h after cardiac surgery)
- Cystatin C(within 48h after cardiac surgery)
- High-sensitivity c-reactive protein(HS-CRP)(within 48h after cardiac surgery)