The Effect of Remote Ischemic Postconditioning on Liver Graft and Renal Function in Patients Undergoing Living-related Liver Transplantation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Ischemia/Reperfusion Injury of Liver Graft
- Sponsor
- Samsung Medical Center
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- total bilirubin
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
The investigators are trying to evaluate the clinical effect of remote ischemic postconditioning on liver graft function and postoperative renal function in subjects undergoing living-donor liver transplantation.
Detailed Description
Ischemic reperfusion injury of liver graft and postoperative renal dysfunction is a common problem which influence poor outcome in subjects undergoing liver transplantation. The incidence of postoperative renal dysfunction was reported as high as 12 \~ 64% and is thought to be caused by ischemia/reperfusion injury. Ischemic pre- or postconditioning was reported to be effective for preventing ischemia/reperfusion injury during liver transplantation. Remote ischemic pre- or postconditioning was also reported to be protective for ischemia/reperfusion injury in major organs in previous animal studies. Therefore, we are trying to evaluate the clinical effect of remote ischemic postconditioning on liver graft function and postoperative renal function in subjects undergoing living-donor liver transplantation.
Investigators
Jong Hwan Lee
Assistant Professor
Samsung Medical Center
Eligibility Criteria
Inclusion Criteria
- •Subjects undergoing living donor liver transplantation during the study period
- •Subjects older than 20 yrs who can give written informed consent
Exclusion Criteria
- •Re-transplanted recipients
- •Those with peripheral vascular diseases affecting the extremities
- •Those with hepatic encephalopathy
- •Those with cirrhotic cardiomyopathy
Outcomes
Primary Outcomes
total bilirubin
Time Frame: before surgery and at 6, 12, 24, 36, 48, 60, 72, 84, 96 hours after the end of surgery
total bilirubin before surgery and at 6, 12, 24, 36, 48, 60, 72, 84, 96 hours after the end of surgery
Secondary Outcomes
- Renal Function Test profiles(Before surgery and at 6, 12, 24, 36, 48, 60, 72, 84, 96 hours after the end of surgery)
- Liver Function Test Profiles(before surgery and at 6, 12, 24, 36, 48, 60, 72, 84, 96 hours after the end of surgery)
- incidence of Surgical Outcome(1 week, 1 month after the end of surgery)
- Length of hospital stay (days)(1 month, 2 month, 3 month after the end of surgery)