The Role of Branched-chain Amino Acids (BCAAs) in the Stimulation of Skeletal Muscle Protein Synthesis and Glucose Uptake in Healthy Young Volunteers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Postprandial muscle protein synthesis
研究概览
简要总结
The present study aims to quantify the insulin sensitivity and the skeletal muscle protein synthetic response to consuming a test drink containing all amino acids or all amino acids except for BCAAs.
详细描述
Twenty-eight healthy, young volunteers will receive a stable isotope tracer infusion (7.5h) combined with repeated blood and muscle sampling, to measure muscle protein synthesis rate in the postabsorptive state following ingestion of a drink containing all amino acids (n=14) or all amino acids except for BCAAs (n=14).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged from 18-35 years
- •18.5 < Body mass index < 30 kg·m2
- •Recreationally active (performing non-competitive physical exercise at least one time per week for minimally 30 minutes)
排除标准
- •Diabetes (Type 1, Type 2, or genetic form of diabetes)
- •Any diagnosed cardiovascular (heart) disease or high blood pressure (≥140 mmHg systolic and/or ≥90 mmHg diastolic)
- •Chronic use of any prescribed or over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices)
- •Known allergy to lidocaine
- •Regular use of dietary protein and/or amino acid supplements (>3 times per week)
- •Currently involved in a structured progressive resistance training programme (>3 times per week)
- •A personal or family history of thrombosis (clots), epilepsy, seizures, or schizophrenia.
- •Any previous motor disorders or disorders in muscle and/or lipid metabolism
- •Presence of an ulcer in the stomach or gut and/or strong history of indigestion
- •Known severe kidney problems
- •Pregnant or breastfeeding
- •Unable to give consent
研究组 & 干预措施
NoBCAA
Amino acid drink containing all amino acids except for BCAAs.
干预措施: Ingestion of an amino acid supplement (Dietary Supplement)
FullAA
Amino acid drink containing all amino acids
干预措施: Ingestion of an amino acid supplement (Dietary Supplement)
结局指标
主要结局
Postprandial muscle protein synthesis
时间窗: 4 hours
Muscle protein synthesis rate (FSR) prior to and following ingestion of an amino acid drink
次要结局
- Forearm amino acid kinetics(Prior to and for 4 hours following amino acid intake)
- Forearm muscle glucose uptake(7.5 hours)
- Whole-body insulin sensitivity(Four hours following ingestion of an amino acid drink)
研究者
Marlou Dirks
Assistant Professor
Wageningen University