Functional analysis of the adaptive immune system in patients with congestive heart failure

• Conditions: Congestive Heart FailureAdults with Congenital Heart Defects; Q20-Q28; I50.9; Congenital malformations of the circulatory system; Heart failure, unspecified

• Registration Number: DRKS00012508
• Lead Sponsor: niversitätsklinikum Freiburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-07-06
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

Adult patients listed for cardiac transplantation at the UHZ Freiburg.
-Adult patients with CHF NYHA II-IV attending the UHZ Freiburg for various reasons
-Adult patients with congenital heart defects at the UHZ Freiburg and one of the following:
Eisenmenger syndrome or history of Fontan´s procedure or = NYHA II

Exclusion Criteria

absence of consent

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of the RTI-score and corresponding immunologic data (Ig levels, lymphocyte counts, vaccination responses) between the trial population and the general population included into the AWIS cohort.<br>

Secondary Outcome Measures

Name	Time	Method
Correlation of RTI-score and hypogammaglobulinemia (defined als IgG levels <7mg/dl) in the trial population. <br>Distribution of B lymphocyte subpopulations in the trial population with hypogammaglobulinemia compared to patients within the trial population with normal Ig values. <br>Frequency of protective antibody titers against pneumococcal antigens in the trial population with hypogammaglobulinemia compared to patients within the trial population with normal Ig values. <br>