The role and modulation of the adaptive immune response in human limb ischaemia reperfusion injury by ischaemic preconditioning
Completed
- Conditions
- Reperfusion injurySurgerySurgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
- Registration Number
- ISRCTN66931248
- Lead Sponsor
- ational University of Ireland Galway (Ireland)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
Patients (both males and females) diagnosed with anterior cruciate ligament rupture by magnetic resonance imaging (MRI) or arthroscopy and undergoing patellar tendon graft reconstruction under tourniquet control.
Exclusion Criteria
1. Age under 18 or over 45
2. Having smoked in the preceding 3 months
3. Diagnosis of systemic auto-immune condition (e.g., thyroxicosis, inflammatory bowel/ coeliac disease, rheumatoid arthritis, systemic lupus erythematosus [SLE])
4. Diabetes
5. Concurrent medical condition
6. Pregnancy
7. Medications other than simple analgesics and non-steroidal anti-inflammatory drugs (NSAID)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method