NCT00311909已完成2 期
Thalamic Deep Brain Stimulation for Tourette Syndrome: A Prospective Clinical Trial
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 5
- 试验地点
- 2
- 主要终点
- modified Rush Video Rating Scale (mRVRS)
研究概览
简要总结
The purpose of this study is to determine whether deep brain stimulation is effective at reducing tic frequency and severity in adults with Tourette syndrome.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age 18 or older
- •Diagnosis of Tourette Syndrome by DSM-IV
- •Tic frequency at least one per minute at screening
- •prior failure of at least two dopamine receptor or presynaptic blockers
- •negative impact on quality of life
排除标准
- •significant structural brain lesion (on imaging studies)
- •significant dementia
- •severe head trauma preceding onset of tics
- •use of dopamine receptor blockers prior to recognition of tics
- •prior implanted electrical device
- •electroconvulsive therapy (ECT) within 24 months
- •suicide attempt within 12 months
- •significant sociopathic personality
- •current or planned pregnancy
结局指标
主要结局
modified Rush Video Rating Scale (mRVRS)
次要结局
- SF-36
- Yale Global Tourette Severity Scale (YGTSS)
- Quality of Life Visual Analog Scale (VAS)
- Neuropsychological battery
- tic counts (on video recording)
- Tourette Syndrome Symptom List (TSSL)
研究者
研究点 (2)
Loading locations...
相似试验
进行中（未招募）
不适用
Tourette Syndrome Deep Brain StimulationTourette SyndromeNCT02056873University of Florida10
撤回
1 期
Optimising Anterior Pallidal Deep Brain Stimulation for Tourette's SyndromeTourette's SyndromeNCT02112253The University of Western Australia
已完成
不适用
Adjunctive Transcranial Stimulation to Reduce Impulsivity in Opiate Use DisorderOpioid-use DisorderTobacco Use DisorderNCT05049460Gopalkumar Rakesh23
已完成
不适用
Deep Brain Stimulation for Patients With Parkinson's Disease.Parkinson DiseaseNCT03128567Institut National de la Santé Et de la Recherche Médicale, France10
已完成
1 期
Deep Brain Stimulation for Treatment-Refractory Major DepressionDepressionNCT00122031University Hospital, Bonn13