Effets de la Stimulation cérébrale Profonde Chez Les Patients âgés Avec Maladie de Parkinson : Essai contrôlé randomisé Multicentrique
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Parkinson Disease
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
- Enrollment
- 10
- Locations
- 7
- Primary Endpoint
- PDQ-39 Quality of life questionnary
- Status
- Completed
- Last Updated
- 11 months ago
Overview
Brief Summary
Deep brain stimulation of the sub thalamic nucleus (STN-DBS) is an efficient treatment to improve motor and non motor signs of Parkinson's disease (PD). In people aged more 70 years, an increased rate of side effects such as post-operative cognitive decline and/or postural instability with falls has been suspected with less improvement in the quality of life. Here, Investigators aim further explore the effects of STN-DBS in 50 patients with PD people aged more 69 years in a randomized parallel controlled study.
Detailed Description
The effects of combined bilateral deep brain stimulation of the subthalamic nucleus and medical treatment on the quality of life will be evaluated in 25 PD patients aged more 69 years in comparison to 25 PD patients aged more 69 years that only received medical drug treatment.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Parkinson's disease
- •disease duration \> 5 years
- •levodopa related motor complications
- •dopasensitivity \> 50%
- •signed informed written consent
- •medical social insurance
Exclusion Criteria
- •contra-indication to neurosurgery
Outcomes
Primary Outcomes
PDQ-39 Quality of life questionnary
Time Frame: Quality of life one year after surgery
PDQ-39 scale