Deep Brain Stimulation for Patients With Parkinson's Disease.
- Conditions
- Parkinson Disease
- Registration Number
- NCT03128567
- Lead Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
- Brief Summary
Deep brain stimulation of the sub thalamic nucleus (STN-DBS) is an efficient treatment to improve motor and non motor signs of Parkinson's disease (PD). In people aged more 70 years, an increased rate of side effects such as post-operative cognitive decline and/or postural instability with falls has been suspected with less improvement in the quality of life. Here, Investigators aim further explore the effects of STN-DBS in 50 patients with PD people aged more 69 years in a randomized parallel controlled study.
- Detailed Description
The effects of combined bilateral deep brain stimulation of the subthalamic nucleus and medical treatment on the quality of life will be evaluated in 25 PD patients aged more 69 years in comparison to 25 PD patients aged more 69 years that only received medical drug treatment.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 10
- Parkinson's disease
- disease duration > 5 years
- levodopa related motor complications
- dopasensitivity > 50%
- signed informed written consent
- medical social insurance
- dementia
- contra-indication to neurosurgery
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method PDQ-39 Quality of life questionnary Quality of life one year after surgery PDQ-39 scale
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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Trial Locations
- Locations (7)
Service d'EFSN, Hôpital Pellegrin
🇫🇷Bordeaux, France
Hôpital Roger Salengro - CHRU de Lille Service de Neurologie et Pathologie du Mouvement
🇫🇷Lille, France
Hôpital Neurologique Pierre Wertheimer, Service de Neurologie
🇫🇷Lyon, France
Département des maladies du Système Nerveux, Hôpital Pitié-Salpétrière
🇫🇷Paris, France
Service de Neurologie, Pôle Neurosciences, CHU de Poitiers
🇫🇷Poitiers, France
CHU Charles Nicolle
🇫🇷Rouen, France
Centre d'Investigation Clinique - CIC 1436. CHU PURPAN. Hôpital Pierre Paul Riquet
🇫🇷Toulouse, France
Service d'EFSN, Hôpital Pellegrin🇫🇷Bordeaux, France