Thalamic Deep Brain Stimulation for Tourette Syndrome
Phase 2
Completed
- Conditions
- Tourette Syndrome
- Registration Number
- NCT00311909
- Lead Sponsor
- University Hospitals Cleveland Medical Center
- Brief Summary
The purpose of this study is to determine whether deep brain stimulation is effective at reducing tic frequency and severity in adults with Tourette syndrome.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 5
Inclusion Criteria
- age 18 or older
- Diagnosis of Tourette Syndrome by DSM-IV
- Tic frequency at least one per minute at screening
- prior failure of at least two dopamine receptor or presynaptic blockers
- negative impact on quality of life
Exclusion Criteria
- significant structural brain lesion (on imaging studies)
- significant dementia
- severe head trauma preceding onset of tics
- use of dopamine receptor blockers prior to recognition of tics
- prior implanted electrical device
- electroconvulsive therapy (ECT) within 24 months
- suicide attempt within 12 months
- significant sociopathic personality
- current or planned pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method modified Rush Video Rating Scale (mRVRS)
- Secondary Outcome Measures
Name Time Method SF-36 Yale Global Tourette Severity Scale (YGTSS) Quality of Life Visual Analog Scale (VAS) Neuropsychological battery tic counts (on video recording) Tourette Syndrome Symptom List (TSSL)
Trial Locations
- Locations (1)
University Hospitals of Cleveland
🇺🇸Cleveland, Ohio, United States