The Analysis of the Sublingual Microvascular Terminal Circuit Improves the Diagnostic and Therapeutic Algorithms in Dehydrated Older Patients- a Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 13
- 试验地点
- 1
- 主要终点
- Change from Baseline of Percentage of Perfusion Vessels [%]
研究概览
简要总结
This proof-of-concept study examines whether 1) sublingual measurement in dehydrated old patients is feasible, 2) frailty and incompliance in old, awake patients affects video-quality, 3) dehydration impacts microcirculation This prospective observational study includes clinically dehydrated patients aged ≥ 65 years, who have spontaneous circulation and access to the sublingual mucosa, immediately after admission. Dehydration will be assessed clinically. A sidestream dark field camera (SDF) will be used for measurement. Video-quality will be evaluated with MIQS (microcirculation image quality score). Both AVA 4.3C- and AVA POEM-software analyzed the videos. Seventeen patients ≥ 65 years not showing dehydration served as control.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •65 years old or older
- •diagnosed with dehydration according to the clinical impression of the treating physician
- •informed consent
- •the sublingual mucosa had to be accessible.
排除标准
- •<65 years
- •Lacking informed consent
- •time-critical disease
- •previous resuscitation
- •inaccessibility of sublingual area
结局指标
主要结局
Change from Baseline of Percentage of Perfusion Vessels [%]
时间窗: at Baseline and after 24 hours
Measurement of sublingual microcirculation by using MicroScan® microscope. AVA 4.3C calculates automatically important microcirculatory values (Percentage of Perfusion Vessels; DeBackerDensity; Perfused DeBackerDensity; Perfused Vessel Density) according to the Second Consensus Conference
次要结局
- Microcirculatory quality score (MIQS)(at Baseline)
- Mini-Mental-Test scoring(at Baseline)
- Barthel scoring(at Baseline)
- Rate of mortality(30 days after discharge)
- Clinical Frailty Scale(at Baseline)
研究者
Klinik für Kardiologie, Pneumologie und Angiologie
Principle Investigator
Heinrich-Heine University, Duesseldorf