NCT03268109已完成不适用
COGnitive ImpairmenT in Older HIV-infected Patients ≥ 65 Years Old.
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 281
- 试验地点
- 1
- 主要终点
- cognitive impairment
研究概览
简要总结
Despite combined antiretroviral therapy (cART), milder forms of HIV-associated neurocognitive disorders (HAND) persist in 20-50% of persons living with HIV (PLHIV). Since more PLH are at risk for HAND due to aging, the frequency of HAND in PLHIV ≥ 65 years old is important to quantify for planning early intervention to attenuate both functional and occupational disabilities due to cognitive impairment.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Personal or familial cognitive complaints
- •Individual aged ≥ 65 years old and < 81 years old
- •Instrumental activities of daily living (IADL) score between 3-4
- •French speaking individual
- •Informed consent signed For PLHIV
- •HIV infection
- •Undetectable HIV viral load ≥ 1 year
- •Current cluster of differentiation (CD4) cell count > 100/mm3 For controls
- •negative HIV serology ≤ 6 months
排除标准
- •Opportunistic infection < 5 years
- •Contraindications to MRI
结局指标
主要结局
cognitive impairment
时间窗: baseline
cognitive impairment frequency, defined by a z-score ≤ 1.65 in at least 2 cognitive domains
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
已完成
4 期
A Study of the Neurological Effects of Adding Maraviroc to HAART Regimen in Patients With HIV (HANDmac)Human Immunodeficiency Virus (HIV)HIV Associated Neurocognitive Disorders (HAND)NCT01449006Bruce Brew19
终止
4 期
A Study of the Neurological Effects of Adding Raltegravir to HAART Regimen in Patients With HIVHuman Immunodeficiency Virus (HIV)HIV Associated Neurocognitive Disorders (HAND)NCT01448486St Vincent's Hospital, Sydney6
已完成
4 期
Integrase and Maraviroc Intensification in Neurocognitive Dysfunction (InMIND)HIV InfectionsNCT02519777National Institute of Allergy and Infectious Diseases (NIAID)191
Unknown
4 期
Neurocognitive Function Improvement After Switching From Efavirenz to RilpivirineNeurocognitive DysfunctionHIV-1-infectionNCT03567304Chiang Mai University28
已完成
不适用
Stanford Universities: The Stanford HIV Aging CohortAcquired Immunodeficiency SyndromeNCT01401348Stanford University154