COVID-19 in Hospitalised Patients With Preexisting CArdioVascular Diseases and/or Cardiac Involvement and/or Cardiovascular Risk Factors: the Global PCHF-COVICAV Registry
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- COVID-19
- Sponsor
- University of Zurich
- Enrollment
- 1500
- Locations
- 1
- Primary Endpoint
- In-hospital mortality.
- Last Updated
- 5 years ago
Overview
Brief Summary
Background: Coronavirus disease (COVID-19) is a tremendous challenge the modern world has never seen before and is overwhelming the capacities of healthcare systems worldwide. Patients with cardiovascular diseases, heart failure in particular, and cardiovascular risk factors seem to be at a very high risk if affected by COVID-19 - and vice versa there are more and more reports of cardiac manifestations with the viral disease.
Aim: The purpose of the study is to characterise the clinical course of adult inpatients with COVID-19 and concomitant cardiovascular affection in a worldwide, multicentre PCHF registry.
Methods: Retrospective and prospective data analysis. Data on demographic, clinical, selected laboratory, electrocardiography and echocardiography parameters, treatment and outcome will be collected. The principal investigator provides dedicated electronic case report form. The primary outcome is in-hospital mortality. The secondary endpoints will be ICU length of stay, hospital length of stay, the need and duration of invasive mechanical ventilation, cardiovascular hospitalisation after 3 and 6 months from index hospitalisation, all-cause and cardiovascular mortality after 3 and 6 months from index hospitalisation.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adult inpatients (≥18 years old) with laboratory-confirmed COVID-19.
Exclusion Criteria
- •Age \<18 years old.
- •Outpatients.
Outcomes
Primary Outcomes
In-hospital mortality.
Time Frame: Hospitalization period, assessed up to 30 days
All-cause and cardiovascular mortality during index hospitalization.
Secondary Outcomes
- Hospitalization for cardiovascular causes or cardiovascular deaths within 3 months after hospitalization.(3 months)
- The duration of hospitalization.(Hospitalization period, assessed up to 30 days)
- The length of stay in the intensive care unit.(Hospitalization period in the ICU, assessed up to 30 days)
- The need and duration of invasive mechanical ventilation.(Hospitalization period, assessed up to 30 days)
- Hospitalization for cardiovascular causes or cardiovascular deaths within 6 months after hospitalization.(6 months)