Myocellular Signalling in Skeletal Muscle

Not Applicable

Completed

• Conditions: Exercise; Insulin Sensitivity
• Interventions: Drug: Insulin; Other: Exercise

• Registration Number: NCT03203317
• Lead Sponsor: University of Copenhagen

Brief Summary

The study will investigate myocellular signalling in skeletal muscle after insulin-stimulation and exercise in healthy young men

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-04-26
• Study Start: 2017-05-01
• Study First Submitted QC: 2017-06-27
• Study First Posted: 2017-06-29
• Status Verified: 2017-07
• Primary Completion: 2017-07-26
• Study Completion: 2017-07-26
• Last Update Submitted: 2017-07-29
• Last Update Posted: 2017-08-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 8

Inclusion Criteria

• healthy
• informed consent
• habitual training (2-5 h/week)
• VO2max of 40-60 ml/min/kg
• lean mass 55-65 kg

Exclusion Criteria

• smoker
• allergy towards insulin
• chronic disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Insulin-stimulation	Insulin	2 h insulin-clamp
Exercise	Exercise	10 min of maximal exercise

Primary Outcome Measures

Name	Time	Method
Change in muscle phospho-proteome signature	Before and after 10 minutes of exercise, as well as before and after a 2 hour insulin stimulation	proteomic analysis of mixed muscle homogenate

Trial Locations

Locations (1)

August Krogh Building; 🇩🇰 Copenahgen, Denmark