Ketone Esters and Metabolism During Recovery from Endurance Exercise

Not Applicable

Active, not recruiting

• Conditions: Exercise; Metabolism

• Registration Number: NCT06846840
• Lead Sponsor: University of Bath

Brief Summary

Infusion of beta-hydroxybutyrate can suppress endogenous glucose production, which may result in increased net liver glycogen storage. If ketone esters exert similar effects, then the increase in liver glycogen storage may have implication for recovery from exercise and subsequent exercise performance.

The aim of this study is to assess the effects of ketone esters ingested during recovery from exercise, on metabolism and subsequent exercise capacity.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-11-01
• Status Verified: 2025-02
• Primary Completion: 2025-02-17
• Study First Submitted: 2025-02-20
• Study First Submitted QC: 2025-02-20
• Last Update Submitted: 2025-02-20
• Study First Posted: 2025-02-26
• Last Update Posted: 2025-02-26
• Study Completion: 2025-05-01

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• VO2max ≥ 45mL.kg-1.min-1
• Weekly aerobic training > 3hours.
• 2years running experience.
• BMI < 30kg/m2

Exclusion Criteria

• <18yrs or >60yrs of age
• Habitual smoker within last 5 years.
• History of uncontrollable metabolic or respiratory disease.
• Currently taking medication, following a low carbohydrate or ketogenic diet, or consuming nutritional ketone supplements.
• History of Irritable Bowel Syndrome

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Glucose concentrations	240 minutes	Blood glucose concentrations during the recovery period (240 minutes)

Secondary Outcome Measures

Name	Time	Method
Non-oxidative fate of ingested sucrose	240 minutes	Non-oxidative fate of ingested glucose measured by appearance of 13C on breath CO2 from high 13C sucrose ingested during recovery
Exercise capacity	240 minutes	Time to exhaustion running at 70% of maximal aerobic capacity after the recovery period

Trial Locations

Locations (1)

University of Bath; 🇬🇧 Bath, United Kingdom