Towards understanding the interplay of inflammation, immunity and circulating cells in atherosclerosis development in young adulthood: a magnetic resonance study

Completed

Conditions: arteriosclerosis
hardening of the arteries
induration of the arteries
10003216

Registration Number: NL-OMON40481

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 520

Inclusion Criteria

- cardiovascular healthy subjects (no medical history of cardiovascular disease and no cardiovascular preventive medication);
- between 25-35 years of age
- willing and be able to sign informed consent.

Exclusion Criteria

- subjects with claustrophobia;
- subjects with a history of allergic reactions to contrast fluids;
- subjects with implanted electronic devices (i.e. pacemaker, internal cardioverter-
defibrillator, cochlear implants, nerve- and bone stimulators);
- subjects with ferromagnetic clips in brain, eyes or lungs;
- subjects with a known reduced kidney function (GFR< 60 ml/min)
- subjects who are pregnant
- subjects who do not wish to be informed of abnormal results

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary endpoints (a) the presence and (b) rate of change in<br /><br>atherosclerosis in the thoracic and abdominal aorta (shown with MR Imaging)<br /><br>over time in young adulthood as predicted by certain biomarkers in order to<br /><br>identify individuals at high risk to develop advanced atherosclerosis over<br /><br>classical risk factors.<br /><br><br /><br>The biomarkers that are involved in this study concern:<br /><br>- biomarkers of circulating cells<br /><br>- plasma biomarkers of systemic inflammation (including micro particles)<br /><br><br /><br>The findings at MR that are of relevance concern:<br /><br>- aortic wall thickness and volume<br /><br>- presence and number of aortic atherosclerotic plaques (luminal protrusion of<br /><br>> 1 mm in radial thickness);<br /><br>- the extent of aortic atherosclerosis (expressed as % of affected aorta as<br /><br>fraction of total aorta depicted).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>There are other study parameters involved in this study, such as demographic<br /><br>characteristics, established risk factors and potential confounders:<br /><br><br /><br>- factors that affect change over time in plasma markers of systemic<br /><br>inflammation and markers of circulating cells;<br /><br>- aortic pulse wave velocity<br /><br>- left ventricle function (LVF)<br /><br>- age<br /><br>- gender<br /><br>- ethnicity<br /><br>- medical history<br /><br>- medication use<br /><br>- lifestyle (smoking, alcohol, consumption, dietary intake, social economic<br /><br>status [income and education level], anthropometry [body mass index, waist<br /><br>circumference, blood pressure, lipid- and glucose levels])</p><br>