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临床试验/NCT02917070
NCT02917070已完成不适用

The Importance of Parental Consanguinity and Family History of Kidney Disease in Turkish Adult Chronic Kidney Disease Population

Istanbul University1 个研究点 分布在 1 个国家目标入组 2,576 人开始时间: 2016年2月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
2,576
试验地点
1
主要终点
Effect of parental consanguinity on chronic kidney disease confirmed by a questionnaire did they have consanguinity marriage or not.

研究概览

简要总结

Inbreeding and consanguineous marriages are known to increase the risk of autosomal recessive disorders. The aim of this study was to examine the association between consanguinity and kidney diseases in the adult Turkish population.

详细描述

This was a national, cross-sectional study recruiting patients from nephrology out-patient clinics and dialysis units. All patients between 18 and 70 years of age who were on follow up in outpatient clinic and dialysis unit at the Istanbul Medical Faculty from October 2009 to October 2015 were included in the study. All patients and healthy controls enrolled in this study gave informed consent to participate in the survey. They were all asked to answer a questionnaire including socio-demographic data, history of familial kidney disease and consanguineous marriage. Additional information was obtained from their private physicians and medical files. To ensure reliability of administration of the questionnaire, all interviewers underwent training using a standardized protocol.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 70 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • follow up in outpatient clinic and dialysis unit at the Istanbul Medical Faculty
  • between 18-70 years old
  • provide informed consent

排除标准

  • follow-up shorter than 6 months
  • patients whose data were not available
  • patients who were unwilling or unable to provide informed consent

结局指标

主要结局

Effect of parental consanguinity on chronic kidney disease confirmed by a questionnaire did they have consanguinity marriage or not.

时间窗: 6 months after enrollment

次要结局

  • Effect of family history of kidney disease on the development of chronic kidney confirmed by a questionnaire did they have any parents with chronic kidney diseases or not.(6 months after enrollment)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Yasar Caliskan

Principal Investigator

Istanbul University

研究点 (1)

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