The Importance of Parental Consanguinity and Family History of Kidney Disease in Turkish Adult Chronic Kidney Disease Population
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2,576
- 试验地点
- 1
- 主要终点
- Effect of parental consanguinity on chronic kidney disease confirmed by a questionnaire did they have consanguinity marriage or not.
研究概览
简要总结
Inbreeding and consanguineous marriages are known to increase the risk of autosomal recessive disorders. The aim of this study was to examine the association between consanguinity and kidney diseases in the adult Turkish population.
详细描述
This was a national, cross-sectional study recruiting patients from nephrology out-patient clinics and dialysis units. All patients between 18 and 70 years of age who were on follow up in outpatient clinic and dialysis unit at the Istanbul Medical Faculty from October 2009 to October 2015 were included in the study. All patients and healthy controls enrolled in this study gave informed consent to participate in the survey. They were all asked to answer a questionnaire including socio-demographic data, history of familial kidney disease and consanguineous marriage. Additional information was obtained from their private physicians and medical files. To ensure reliability of administration of the questionnaire, all interviewers underwent training using a standardized protocol.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 70 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •follow up in outpatient clinic and dialysis unit at the Istanbul Medical Faculty
- •between 18-70 years old
- •provide informed consent
排除标准
- •follow-up shorter than 6 months
- •patients whose data were not available
- •patients who were unwilling or unable to provide informed consent
结局指标
主要结局
Effect of parental consanguinity on chronic kidney disease confirmed by a questionnaire did they have consanguinity marriage or not.
时间窗: 6 months after enrollment
次要结局
- Effect of family history of kidney disease on the development of chronic kidney confirmed by a questionnaire did they have any parents with chronic kidney diseases or not.(6 months after enrollment)
研究者
Yasar Caliskan
Principal Investigator
Istanbul University
