Parental Consanguinity and Family History of Kidney Disease in Turkish Kidney Disease Population

Completed

• Conditions: Hereditary Diseases
• Interventions: Other: Patients

• Registration Number: NCT02917070
• Lead Sponsor: Istanbul University

Brief Summary

Inbreeding and consanguineous marriages are known to increase the risk of autosomal recessive disorders. The aim of this study was to examine the association between consanguinity and kidney diseases in the adult Turkish population.

Detailed Description

This was a national, cross-sectional study recruiting patients from nephrology out-patient clinics and dialysis units. All patients between 18 and 70 years of age who were on follow up in outpatient clinic and dialysis unit at the Istanbul Medical Faculty from October 2009 to October 2015 were included in the study. All patients and healthy controls enrolled in this study gave informed consent to participate in the survey. They were all asked to answer a questionnaire including socio-demographic data, history of familial kidney disease and consanguineous marriage. Additional information was obtained from their private physicians and medical files. To ensure reliability of administration of the questionnaire, all interviewers underwent training using a standardized protocol.

Study Timeline

• Study Start: 2016-02
• Primary Completion: 2016-05
• Study Completion: 2016-08
• Status Verified: 2016-09
• Study First Submitted: 2016-09-09
• Study First Submitted QC: 2016-09-26
• Last Update Submitted: 2016-09-26
• Study First Posted: 2016-09-28
• Last Update Posted: 2016-09-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 2576

Inclusion Criteria

• follow up in outpatient clinic and dialysis unit at the Istanbul Medical Faculty
• between 18-70 years old
• provide informed consent

Exclusion Criteria

• follow-up shorter than 6 months
• patients whose data were not available
• patients who were unwilling or unable to provide informed consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients	Patients	Patients who have chronic kidney diseases

Primary Outcome Measures

Name	Time	Method
Effect of parental consanguinity on chronic kidney disease confirmed by a questionnaire did they have consanguinity marriage or not.	6 months after enrollment

Secondary Outcome Measures

Name	Time	Method
Effect of family history of kidney disease on the development of chronic kidney confirmed by a questionnaire did they have any parents with chronic kidney diseases or not.	6 months after enrollment

Trial Locations

Locations (1)

Istanbul University, Istanbul Faculty of Medicine; 🇹🇷 Istanbul, Turkey