Efficacy of Ketofol (drug) for critically ill patients with liverdisease.
Phase 2
- Conditions
- Health Condition 1: K721- Chronic hepatic failure
- Registration Number
- CTRI/2024/04/066049
- Lead Sponsor
- Institute of Liver and Biliary Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Age 18years or more
2.Advanced liver disease with MELDNa 15 or more
3.Undergoing elective endotracheal intubation
Exclusion Criteria
1.
2.Refusal to consent
3.Allergic to any of the agents being used
4.Pregnancy
5.Patients needing CPR
6.Patients with anticipated difficult airway
7.Acute liver failure
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - To compare the incidence of post intubation hypotension occurring within 6 hours of intubation <br/ ><br>between etomidate and ketofol use for sedation during endotracheal intubations in liver ICUTimepoint: Within 6 hours
- Secondary Outcome Measures
Name Time Method 7-day mortalityTimepoint: first 7 days post intubation;Fall /Change in MAP from baseline for 1st 6 hours after intubationTimepoint: Within 6 hours post intubation;Incidence of post intubation hypertension within 6 hours of intubationTimepoint: Within 6 hours post intubation;Intubation difficulty scoreTimepoint: Day 0;Length of ICU stayTimepoint: 7 days;Number of days on ventilatorTimepoint: 7 days;Number of patients requiring vasopressors within 24 hrs of intubationTimepoint: within 24 hours post intubation;SOFA score at 1 hr and 24 hours post intubationTimepoint: 1 hr and 24 hrs after intubation;Total and peak dose of vasopressor requirement within 24 hrs post intubationTimepoint: within 24 hours of intubation