Comparison of Dialysis Strategies in Critically Ill Patients With Acute Renal Failure
- Conditions
- DialysisAcute Renal Failure
- Interventions
- Procedure: Renal replacement therapy
- Registration Number
- NCT00322530
- Lead Sponsor
- Heidelberg University
- Brief Summary
The goal of the present study is the comparison of different dialysis strategies in critically ill patients with acute renal failure on the intensive care unit. Patients are treated with either continuous dialysis or hemofiltration. Outcome measures are death, restitution of renal function, days on ICU, hemodynamic stability, dialysis efficiency.
- Detailed Description
The goal of the present study is the comparison of different renal replacement strategies in critically ill patients with acute renal failure on the intensive care unit. In a prospectively randomized clinical study patients are treated with either continuous dialysis (SLED) or continuous hemofiltration (CVVHD). 200 patients should be included in the study (n=100 each). The primary outcome is death at ICU, secondary outcome measures are restitution of renal function, days on ICU, hemodynamic stability, dialysis efficiency.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 230
- Patients 18 years or older
- Written informed consent
- No pre-existing dialysis dependency
- Minors / children
- No consent
- Severe electrolyte disturbances which necessitates special dialysis therapy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description CVVHD Renal replacement therapy - SLED Renal replacement therapy -
- Primary Outcome Measures
Name Time Method Death 90 days
- Secondary Outcome Measures
Name Time Method costs in hospital Restitution of renal function 90 days days on ICU in hospital hemodynamic stability in hospital dialysis efficiency in hospital
Trial Locations
- Locations (1)
Division of Nephrology, University of Heidelberg
🇩🇪Heidelberg, Baden-Wurttemberg, Germany