Morphology of olfaction-related brain regions and brain functionality in response to odor exposure in healthy participants

Recruiting

• Conditions: reukvermogen; anosmia; smell loss; smelling ability; 10007951

• Registration Number: NL-OMON49925
• Lead Sponsor: Wageningen Universiteit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Self-reported healthy
No known smell disorder
No history of head trauma
No neurological disorders (like Alzheimer*s or Parkinson*s disease)
Labelled as having a normal sense of smell according to our standardized
clinical olfactory test Sniffin* Sticks) (score >= 30.5 points out of 48 points)
Age between 18-75 years
Have normal eyesight or an eye deviation that can be corrected with glasses or
contact lenses.
Willing to comply with the study procedures
Willing to be informed about incidental findings of pathology and approving of
reporting this to their general physician
Having given written informed consent (see E1.Informatiebrochure)

Exclusion Criteria

Having a contra-indication to MRI scanning (including, but not limited to):
o Being pregnant
o Pacemakers and defibrillators
o Intraorbital or intraocular metallic fragments
o Ferromagnetic implants
o Claustrophobia

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) volume of olfaction-related brain areas; 2) activation of brain areas during<br /><br>odor stimulation compared to the control condition.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1) olfactory function and its relation with the primary study parameters; 2)<br /><br>activation of functional brain networks </p><br>