eural processing of olfactory stimuli in response to smell loss

• Conditions: reukvermogen; anosmia; smell loss; 10007951

• Registration Number: NL-OMON50783
• Lead Sponsor: Wageningen Universiteit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

For patients:
* Labelled as hyposmic or anosmic according to a standardised olfactory test
* Smell loss due to a viral infection
* Aged between 18-65 years
* Have normal/ corrected to normal eyesight
* Willing to follow the study procedures
* Having given written informed consent
* Righthanded

For controls:
* Self-reported healthy
* Labelled as normosmic according to a standardised olfactory test
* Aged between 18-65 years
* Have normal/ corrected to normal eyesight
* Willing to follow the study procedures
* Having given written informed consent
* Matched on sex to patient
* Matched on age (within +/- 3 years) to patient
* Righthanded

Exclusion Criteria

* Having congenital anosmia (because olfactory networks will be different from
people who have been able to smell)
* Having suffered from head trauma
* Having chronic (neurological) diseases which impact brain functioning (e.g.
mental health disorder, epilepsy)
* Having fluctuating smell ability
* Being deaf (or having hearing problems) or blind
* Being an employee at the division of Human Nutrition and Health at Wageningen
University
* Performing a thesis or internship at the chair group Sensory Science and
Eating Behaviour at the division of Human Nutrition and Health at Wageningen
University

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Difference in event-related potentials in response to olfactory stimuli between<br /><br>patients with smell loss and controls</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Score on the Sniffin' Sticks test (smell test) of participants and its<br /><br>correlation with N1 and P2 amplitudes of olfactory ERPs.</p><br>