Effects of Aerobic Training on Exercise Capacity in Patients With Advanced Cirrhosis 2
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Change in peak exercise pulmonary oxygen uptake (peak V02)
研究概览
简要总结
Cirrhosis is associated with a reduction in muscle mass and exercise capacity. This has an impact on morbidity and mortality. Regular aerobic exercise training is a proven effective therapy to improve exercise capacity in healthy and clinical populations. The effect of this training has not yet been evaluated in the decompensated cirrhosis patient population. The safety of this intervention also requires further study. Using a randomized controlled design, the investigators aim to determine the safety and efficacy of eight weeks of aerobic exercise training on aerobic capacity, functional performance, and muscle mass in decompensated cirrhosis patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age >18 and ≤ 70 years
- •Cirrhosis
- •Child Pugh class B or C
- •If required, primary or secondary variceal prophylaxis in place
排除标准
- •Post-liver transplantation
- •Hepatocelluar carcinoma beyond transplant criteria
- •Active non-hepatocelluar carcinoma malignancy
- •Significant cardiac disease
- •Hemoglobin (<80 g/L)
- •Oxygen saturation at rest <95%
- •Known myopathy
- •Chronic renal failure on dialysis
- •Physical impairment making it impossible to ride an exercise bike or treadmill
- •Orthopedic abnormality preventing exercise training
- •HIV infection
- •Patient unwilling to consent to study
结局指标
主要结局
Change in peak exercise pulmonary oxygen uptake (peak V02)
时间窗: Baseline (day1) and Study End (8 weeks)
次要结局
- Change in muscle mass as measured by thigh ultrasound(Baseline (day 1) and Study End (8 weeks))
- Change in quality of life-Chronic Liver Disease Questionnaire(Baseline (day1) and Study End (8 weeks))