Association of Air Quality and Myocardial Infarction

Completed

• Conditions: Acute Myocardial Infarction

• Registration Number: NCT02880436
• Lead Sponsor: Medical University of Graz

Brief Summary

Besides classical cardiovascular risk factors such as smoking, obesity, elevated cholesterol levels and diabetes there are also acute factors potentially triggering acute coronary events. The impact of various substances and air pollution are described.

Particulate matter, especially with small particle size (\<2.5µm) has been shown to have a positive correlation with myocardial infarctions. However, other studies failed to show this correlation.

With respect to nitric oxydes the majority of published studies detected a significant correlation with myocardial infarction, too, although a highly ranked publication failed to show the same result. In addition data on the impact of sulfur dioxide and carbon monoxide concentration on cardiac events is very heterogeneous.

Published data indicates additive effects of age and other epidemiological variables suggesting the need of a multivariate analysis.

The rationale of the study is to test if the above mentioned air pollution factors have a significant and independent impact on the incidence of myocardial infarctions

Detailed Description

The analysis will be performed in a well characterized patient cohort of 12.000 myocardial infarctions within 10 years being invasively diagnosed at the catheterisation centers of the styrian capital Graz.

Study Timeline

• Study Start: 2007-01
• Study First Submitted: 2016-08-16
• Study First Submitted QC: 2016-08-22
• Study First Posted: 2016-08-26
• Primary Completion: 2017-06-30
• Study Completion: 2017-06-30
• Status Verified: 2017-08
• Last Update Submitted: 2017-08-24
• Last Update Posted: 2017-08-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12000

Inclusion Criteria

• myocardial infarction being confirmed or treated in the cathlab

Exclusion Criteria

• none

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
myocardial infarction	1 day	the number of myocardial infarctions of every day analysed in this study will be correlated with the respective values of air polluting substances

Trial Locations

Locations (1)

Medical University of Graz; 🇦🇹 Graz, Austria