Woodsmoke Exposure and Cardiovascular Function

Not Applicable

Completed

• Conditions: Respiratory Inflammation; Systemic Inflammation
• Interventions: Other: Bronchoscopy

• Registration Number: NCT01488500
• Lead Sponsor: University of Edinburgh

Brief Summary

Air pollution is linked to respiratory and cardiovascular disease. Wood smoke is a common air in many parts of the world and previous studies indicate that wood smoke induce oxidative stress in the respiratory tract. It is not determined how different types of biomass combustion affect human health. In this study the investigators plan to investigate how inhalation of wood smoke and pellets smoke affect respiratory and cardiovascular health.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-11
• Study First Submitted: 2011-12-06
• Study First Submitted QC: 2011-12-07
• Study First Posted: 2011-12-08
• Primary Completion: 2012-05
• Study Completion: 2012-05
• Status Verified: 2012-08
• Last Update Submitted: 2012-08-03
• Last Update Posted: 2012-08-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Healthy volunteers

Exclusion Criteria

• Use of regular medication except the oral contraceptive pill
• Current smokers
• Significant occupation exposure to air pollution
• Intercurrent illness

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Filtered air exposure	Bronchoscopy	3 hour exposure to filtered air with intermittent exercise
Wood smoke exposure	Bronchoscopy	3 hour exposure to dilute wood smoke generated from incomplete combustion in a wood burning stove at approximately 300 mcg/m3
Wood pellet smoke emission	Bronchoscopy	3 hour exposure to dilute wood smoke generated from wood pellets during incomplete combustion during intermittent exercise at approximately 300 mcg/m3

Primary Outcome Measures

Name	Time	Method
Respiratory inflammation	24 hours after exposure to air or woodsmoke	Bronchoscopy will be performed, and samples collected by bronchoalveolar lavage and bronchial biopsy. Samples will be analysed for cell counts, histology and inflammatory markers.

Secondary Outcome Measures

Name	Time	Method
Central arterial stiffness	Baseline and for 1 hour after exposure	Central arterial stiffness will be measured at baseline and for the 1 hour following the exposure using the SphygmoCor and Vicorder devices
Heart rate variability	24 hours after the exposure	Continuous electrocardiograms will be recorded using a holter monitor to determine heart rate variability
Systemic inflammation	24 hours after the exposure	Blood samples will be taken at intervals following the exposure to woodsmoke to measure circulating inflammatory markers
Lung function	Baseline and 24hrs after exposure	Lung function will be assessed using spirometry before and after each exposure

Trial Locations

Locations (1)

Umeå University; 🇸🇪 Umeå, Sweden