Seminal fluid and reproductive health in wome

Not Applicable

Recruiting

• Conditions: the effect of seminal fluid on female endometrial tissue; Reproductive Health and Childbirth - Other reproductive health and childbirth disorders

• Registration Number: ACTRN12610000040066
• Lead Sponsor: niversity of Adelaide

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-01-14
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 36

Inclusion Criteria

healthy volunteer women
having regular menstrual cycles (26-32 days)
have undergone or planning to have a tubal ligation
have a partner with proven fertility, (paternity in another relationship is allowed)
be currently sexually active

Exclusion Criteria

women using steroidal contraceptives, an intrauterine device contraception during the preceding two months. Barrier contraception is allowed.
women with active symptoms of infection
women whose partners are vasectomised or azoospermic

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
determine a similar but distinct inflammatory cytokine response in cervical cells and endometrium after sexual intercourse for histochemical analysis. A sample will also be placed into RNAlater for extraction of ribonucleic acid (RNA) for quantative reverse transcription (qRT) polymerase chain reaction (PCR) and Affymetrix microarray analysis.[10 - 12 hours following intercourse at the time of the LH surge during a menstrual cycle]

Secondary Outcome Measures

Name	Time	Method
A blood sample will be collected at the time of endometrial biopsy to determine any effect of seminal fluid on number and phenotype of circulating T lymphocyte populations.[10 - 12 hours following intercourse at the time of the LH surge during a menstrual cycle]