Evaluation of First-Trimester Maternal Serum Resistin in Hyperemesis Gravidarum
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hyperemesis Gravidarum - Severe
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
- Enrollment
- 210
- Locations
- 1
- Primary Endpoint
- PUQE
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
This cross-sectional case-control study was conducted in Tuzla State Hospital Obstetrics Clinic in Turkey. The study evaluated 400 pregnant women during their first trimester of pregnancy. Many pregnant women (50-90%) experience nausea and vomiting during their first trimester; however, some patients have a disease called "hyperemesis gravidarum" (HG) characterized by very severe nausea and vomiting that may require hospitalization. resistin" is a peptide which is secreted primarily by human adipocytes and mononuclear cells. Evidence suggests that resistin increases plasma glucose concentration, reduces glucose intake by adipocytes, and promotes insulin resistance. Considering the HG effect on endocrinologic and metabolic complications, we hypothesized that resistin levels in maternal serum may change in the presence of HG; therefore, the aim of the present study was to evaluate these resistin levels during the first trimester and their correlation with HG severity.
Investigators
Mehmet Mete Kırlangıç
Assoc Prof
Dr. Lutfi Kirdar Kartal Training and Research Hospital
Eligibility Criteria
Inclusion Criteria
- •Those who applied in the first trimester and had a mid-trimester OGTT result
Exclusion Criteria
- •multifetal pregnancy, 2) fetal chromosomal or structural anomalies, 3) pregestational DM, 4) chronic hypertension or history of preeclampsia, 5) thyroid disease, 5) chronic kidney disease, 6) autoimmune disease, or 7) long-term use of aspirin or glucocorticoids 8) without OGTT results.
Outcomes
Primary Outcomes
PUQE
Time Frame: Immediately after admission in the first trimester
the PUQE-24 questionnaire was used to evaluate the severity of HG, and those with a score of ≤6 were considered as mild HG, 6-12 as moderate HG, and ≥13 as severe HG
Secondary Outcomes
- Resistin levels(Immediately after admission in the first trimester)
- OGTT(admission in 24-28 th week in pregnancy)