A Study to Evaluate Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis
- Registration Number
- NCT05601882
- Lead Sponsor
- AbbVie
- Brief Summary
Atopic dermatitis (AD) is a skin condition that may cause a rash and itching due to inflammation of the skin. Therapies spread over the skin may not be enough to control the AD in trial participants who require systemic anti-inflammatory treatment. This study compares upadacitinib to dupilumab in adolescent and adult participants with moderate to severe AD who have inadequate response to systemic therapies. Adverse events and change in the disease activity will be assessed.
Upadacitinib and dupilumab are approved drugs for the treatment of moderate to severe atopic dermatitis (AD). The study is comprised of a 35-day Screening Period, a 16-week treatment Period 1 and a 16-week treatment Period 2. Participants are randomly assigned to 1 of 2 groups called treatment arms to receive upadacitinib Dose A or dupilumab in Period 1. There is a 30-day or 12-week follow-up visit for those on upadacitinib or dupilumab respectively, who will not enter Period 2. In Period 2, participants will receive upadacitinib Dose A or Dose B for 16 weeks, followed by a 30-day follow-up visit. Approximately 880 adolescent and adult participants ages 12 to 64 with moderate to severe AD who are candidates for systemic therapy will be enrolled at up to 330 sites worldwide.
There may be higher treatment burden for participants in this trial compared to their standard of care . Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 920
- Chronic atopic dermatitis (AD) with onset of symptoms at least 3 years prior to baseline and participant meets Hanifin and Rajka criteria.
- Eczema area and severity index (EASI) score ≥ 16;validated Investigator´s Global Assessment for AD (vIGA-AD) score ≥ 3 and ≥ 10% Body Surface Area Involvement of Atopic Dermatitis (BSA of AD) involvement at the Baseline Visit.
- Baseline weekly average of daily Worst Pruritus Numerical Rating Scale (WP-NRS) ≥ 4.
- Documented history of inadequate response to previous systemic treatment defined as documented history of previous inadequate response to at least one prior systemic treatment for AD OR for whom other systemic treatments are otherwise medically inadvisable.
- History of clinically significant (per investigator's judgment) drug or alcohol abuse within the last 6 months.
- History of an organ transplant which requires continued immunosuppression.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Dupilumab (Period 1) Dupilumab Adult participants received a loading dose of 600 mg dupilumab by subcutaneous (SC) injection at the Baseline visit followed by 300 mg dupilumab SC every other week (EOW) until Week 16. Adolescents (12 to 17 years of age and weighing at least 40 kg) received treatment according to their body weight. Participants weighing 40 to \< 60 kg received a loading dose of 400 mg dupilumab SC at the Baseline visit followed by 200 mg SC EOW until Week 16. Those weighing 60 kg or more received a loading dose of 600 mg dupilumab SC at the Baseline visit followed by 300 mg dupilumab SC EOW until Week 16. Upadacitinib (Period 1) Upadacitinib Participants received 15 mg upadacitinib orally once a day (QD) up to Week 16. Starting at Week 4, participants had their dose increased to 30 mg QD if they had a \< 50% reduction from Baseline in Eczema Area and Severity Index (EASI 50) response or a \< 4-point improvement from Baseline in Worst Pruritus Numerical Rating Scale (WP-NRS; weekly average). Starting at Week 8, participants had their dose increased to 30 mg QD if they had a \< EASI 75 response. Dupilumab -> Upadacitinib (Period 2) Upadacitinib At Week 16, participants receiving dupilumab as per its label in Period 1 were reassigned based on their Eczema Area and Severity Index (EASI) response. Those with \< EASI 75 were offered the option to receive oral doses of upadacitinib 15 mg QD in Period 2 up to Week 32. Those with ≥ EASI 75 completed the end of study procedures. Starting at Week 20, participants with \< EASI 75 or a \< 4-point improvement from Baseline in Worst Pruritus Numerical Rating Scale (WP-NRS; weekly average) had their dose increased to 30 mg QD up to Week 32. Upadacitinib -> Upadacitinib 30 mg (Period 2) Upadacitinib At Week 16, participants receiving upadacitinib in Period 1 were reassigned based on their Eczema Area and Severity Index (EASI) response. Those with \< EASI 75 were allocated or continued to receive upadacitinib 30 mg QD in Period 2. Those with ≥ EASI 75 completed the end of study procedures.
- Primary Outcome Measures
Name Time Method Percentage of Participants Achieving a ≥ 90% Reduction From Baseline in Eczema Area and Severity Index Score (EASI 90) and Worst Pruritus Numerical Rating Scale of 0 or 1 (WP-NRS 0/1) at Week 16 Baseline and Week 16 The EASI is a composite index with scores ranging from 0 to 72. Four AD disease characteristics (erythema, thickness \[induration, papulation, edema\], scratching \[excoriation\], and lichenification) assessed for severity on a scale of "0" (absent) through "3" (severe). In addition, the area of AD involvement is assessed as a percentage by body area of head, trunk (including the genital area), upper extremities, and lower extremities (including the buttocks), and converted to a score of 0 to 6. In each body region, the area is expressed as 0, 1 (1% to 9%), 2 (10% to 29%), 3 (30% to 49%), 4 (50% to 69%), 5 (70% to 89%), or 6 (90% to 100%).
The Worst Pruritus NRS is an assessment tool that participants used to report the intensity of their pruritus during a 24-hour recall period using an electronic hand-held device. Participants rated itch (pruritus) intensity at its worst during the past 24 hours on an 11-point scale from 0 (no itch) to 10 (worst imaginable itch).
- Secondary Outcome Measures
Name Time Method Percentage of Participants Achieving a ≥ 90% Reduction From Baseline in Eczema Area and Severity Index Score (EASI 90) at Week 16 Baseline and Week 16 The EASI is a composite index with scores ranging from 0 to 72. Four AD disease characteristics (erythema, thickness \[induration, papulation, edema\], scratching \[excoriation\], and lichenification) assessed for severity on a scale of "0" (absent) through "3" (severe). In addition, the area of AD involvement is assessed as a percentage by body area of head, trunk (including the genital area), upper extremities, and lower extremities (including the buttocks), and converted to a score of 0 to 6. In each body region, the area is expressed as 0, 1 (1% to 9%), 2 (10% to 29%), 3 (30% to 49%), 4 (50% to 69%), 5 (70% to 89%), or 6 (90% to 100%).
Percentage of Participants Achieving a Worst Pruritus Numerical Rating Scale of 0 or 1 (WP-NRS 0/1) at Week 16 Among Participants With Baseline WP-NRS > 1 Baseline and Week 16 The Worst Pruritus NRS is an assessment tool that participants used to report the intensity of their pruritus during a 24-hour recall period using an electronic hand-held device. Participants rated itch (pruritus) intensity at its worst during the past 24 hours on an 11-point scale from 0 (no itch) to 10 (worst imaginable itch).
Percentage of Participants Achieving an Improvement (Reduction) in Worst Pruritus Numerical Rating Scale (WP-NRS) ≥ 4 at Week 16 Among Those With Baseline WP-NRS ≥ 4 Baseline and Week 16 The Worst Pruritus NRS is an assessment tool that participants used to report the intensity of their pruritus during a 24-hour recall period using an electronic hand-held device. Participants rated itch (pruritus) intensity at its worst during the past 24 hours on an 11-point scale from 0 (no itch) to 10 (worst imaginable itch).
Percentage of Participants Achieving a Worst Pruritus Numerical Rating Scale of 0 or 1 (WP-NRS 0/1) at Week 4 Among Participants With Baseline WP-NRS > 1 Baseline and Week 4 The Worst Pruritus NRS is an assessment tool that participants used to report the intensity of their pruritus during a 24-hour recall period using an electronic hand-held device. Participants rated itch (pruritus) intensity at its worst during the past 24 hours on an 11-point scale from 0 (no itch) to 10 (worst imaginable itch).
Percentage of Participants Achieving a Worst Pruritus Numerical Rating Scale of 0 or 1 (WP-NRS 0/1) at Week 2 Among Participants With Baseline WP-NRS > 1 Baseline and Week 2 The Worst Pruritus NRS is an assessment tool that participants used to report the intensity of their pruritus during a 24-hour recall period using an electronic hand-held device. Participants rated itch (pruritus) intensity at its worst during the past 24 hours on an 11-point scale from 0 (no itch) to 10 (worst imaginable itch).
Percentage of Participants Achieving a ≥ 90% Reduction From Baseline in Eczema Area and Severity Index Score (EASI 90) at Week 4 Baseline and Week 4 The EASI is a composite index with scores ranging from 0 to 72. Four AD disease characteristics (erythema, thickness \[induration, papulation, edema\], scratching \[excoriation\], and lichenification) assessed for severity on a scale of "0" (absent) through "3" (severe). In addition, the area of AD involvement is assessed as a percentage by body area of head, trunk (including the genital area), upper extremities, and lower extremities (including the buttocks), and converted to a score of 0 to 6. In each body region, the area is expressed as 0, 1 (1% to 9%), 2 (10% to 29%), 3 (30% to 49%), 4 (50% to 69%), 5 (70% to 89%), or 6 (90% to 100%).
Percentage of Participants Achieving a ≥ 75% Reduction From Baseline in Eczema Area and Severity Index Score (EASI 75) at Week 2 Baseline and Week 2 The EASI is a composite index with scores ranging from 0 to 72. Four AD disease characteristics (erythema, thickness \[induration, papulation, edema\], scratching \[excoriation\], and lichenification) assessed for severity on a scale of "0" (absent) through "3" (severe). In addition, the area of AD involvement is assessed as a percentage by body area of head, trunk (including the genital area), upper extremities, and lower extremities (including the buttocks), and converted to a score of 0 to 6. In each body region, the area is expressed as 0, 1 (1% to 9%), 2 (10% to 29%), 3 (30% to 49%), 4 (50% to 69%), 5 (70% to 89%), or 6 (90% to 100%).
Percentage of Participants Achieving a 100% Reduction From Baseline in Eczema Area and Severity Index Score (EASI 100) at Week 16 Baseline and Week 16 The EASI is a composite index with scores ranging from 0 to 72. Four AD disease characteristics (erythema, thickness \[induration, papulation, edema\], scratching \[excoriation\], and lichenification) assessed for severity on a scale of "0" (absent) through "3" (severe). In addition, the area of AD involvement is assessed as a percentage by body area of head, trunk (including the genital area), upper extremities, and lower extremities (including the buttocks), and converted to a score of 0 to 6. In each body region, the area is expressed as 0, 1 (1% to 9%), 2 (10% to 29%), 3 (30% to 49%), 4 (50% to 69%), 5 (70% to 89%), or 6 (90% to 100%).
Trial Locations
- Locations (257)
Medical Dermatology Specialists /ID# 250212
🇺🇸Phoenix, Arizona, United States
Alliance Dermatology and Mohs Center /ID# 249671
🇺🇸Phoenix, Arizona, United States
Clinical Trials Institute - Northwest Arkansas /ID# 249838
🇺🇸Fayetteville, Arkansas, United States
Arkansas Research Trials /ID# 250722
🇺🇸North Little Rock, Arkansas, United States
Joseph Raoof Md,Inc /Id# 250211
🇺🇸Encino, California, United States
First OC Dermatology /ID# 250686
🇺🇸Fountain Valley, California, United States
Antelope Valley Clinical Trials /ID# 249946
🇺🇸Lancaster, California, United States
Dermatology Research Associates /ID# 249829
🇺🇸Los Angeles, California, United States
University of California Davis Health /ID# 250044
🇺🇸Sacramento, California, United States
Clinical Trials Research Institute /ID# 250213
🇺🇸Thousand Oaks, California, United States
Western States Clinical Res /ID# 250274
🇺🇸Wheat Ridge, Colorado, United States
UConn Health /ID# 253807
🇺🇸Farmington, Connecticut, United States
Yale Center for Clinical Investigation /ID# 254791
🇺🇸New Haven, Connecticut, United States
Clearlyderm Dermatology /ID# 250457
🇺🇸Boca Raton, Florida, United States
Skin Care Research Boca Raton /ID# 250458
🇺🇸Boca Raton, Florida, United States
Olympian Clinical Research /ID# 250453
🇺🇸Clearwater, Florida, United States
Skin Care Research - Hollywood /ID# 250459
🇺🇸Hollywood, Florida, United States
Solutions Through Adv Rch /ID# 250455
🇺🇸Jacksonville, Florida, United States
GSI Clinical Research, LLC /ID# 250768
🇺🇸Margate, Florida, United States
Wellness Clinical Research - Miami Lakes /ID# 250236
🇺🇸Miami Lakes, Florida, United States
D&H National Research Centers /ID# 250734
🇺🇸Miami, Florida, United States
Florida International Rsrch cr /ID# 249667
🇺🇸Miami, Florida, United States
Tory P Sullivan, MD PA /ID# 251136
🇺🇸North Miami Beach, Florida, United States
Precision Clinical Research /ID# 250990
🇺🇸Sunrise, Florida, United States
Advanced Clinical Research Institute /ID# 250460
🇺🇸Tampa, Florida, United States
Metabolic Research Inst /ID# 250046
🇺🇸West Palm Beach, Florida, United States
Treasure Valley Medical Research /ID# 250727
🇺🇸Boise, Idaho, United States
Dawes Fretzin, LLC /ID# 250276
🇺🇸Indianapolis, Indiana, United States
Randall Dermatology of West Lafayette /ID# 250234
🇺🇸West Lafayette, Indiana, United States
Beth Israel Deaconess Medical Center /ID# 251212
🇺🇸Boston, Massachusetts, United States
Beacon Clinical Research, LLC /ID# 251412
🇺🇸Quincy, Massachusetts, United States
Clarkston Dermatology /ID# 250225
🇺🇸Clarkston, Michigan, United States
Henry Ford Medical Center - New Center One /ID# 250228
🇺🇸Detroit, Michigan, United States
Cleaver Dermatology /ID# 250725
🇺🇸Kirksville, Missouri, United States
MediSearch Clinical Trials /ID# 250272
🇺🇸Saint Joseph, Missouri, United States
Duplicate_Allergy, Asthma & Immunology Associates, PC /ID# 250616
🇺🇸Lincoln, Nebraska, United States
Physician Research Collaboration, LLC /ID# 251099
🇺🇸Lincoln, Nebraska, United States
Montefiore Medical Center - Moses Campus /ID# 251214
🇺🇸Bronx, New York, United States
Derm of Greater Columbus /ID# 250049
🇺🇸Bexley, Ohio, United States
Univ Hosp Cleveland /ID# 250699
🇺🇸Cleveland, Ohio, United States
Wright State Physicians - Fairborn /ID# 254167
🇺🇸Fairborn, Ohio, United States
Vital Prospects Clinical Research Institute, PC /ID# 249840
🇺🇸Tulsa, Oklahoma, United States
Oregon Dermatology and Research Center /ID# 250726
🇺🇸Portland, Oregon, United States
Oregon Medical Research Center /ID# 249666
🇺🇸Portland, Oregon, United States
Oregon Medical Research Center /ID# 250712
🇺🇸Portland, Oregon, United States
University of Pittsburgh MC /ID# 251208
🇺🇸Pittsburgh, Pennsylvania, United States
Duplicate_Medical University of South Carolina /ID# 251218
🇺🇸Charleston, South Carolina, United States
Health Concepts /ID# 250988
🇺🇸Rapid City, South Dakota, United States
International Clinical Research - Tennessee LLC /ID# 250724
🇺🇸Murfreesboro, Tennessee, United States
Arlington Research Center, Inc /ID# 250468
🇺🇸Arlington, Texas, United States
Orion Clinical Research /ID# 250473
🇺🇸Austin, Texas, United States
Bellaire Dermatology Associates /ID# 250739
🇺🇸Bellaire, Texas, United States
Modern Research Associates, PLLC /ID# 250688
🇺🇸Dallas, Texas, United States
Center for Clinical Studies - Houston - Northwest Freeway /ID# 250039
🇺🇸Houston, Texas, United States
Texas Dermatology and Laser Specialists /ID# 250367
🇺🇸San Antonio, Texas, United States
University of Utah /ID# 250042
🇺🇸Murray, Utah, United States
University of Virginia - Dermatology /ID# 254166
🇺🇸Charlottesville, Virginia, United States
Virginia Clinical Research, Inc. /ID# 249908
🇺🇸Norfolk, Virginia, United States
Premier Specialist /ID# 250572
🇦🇺Kogarah, New South Wales, Australia
Veracity Clinical Research /ID# 249943
🇦🇺Woolloongabba, Queensland, Australia
Skin Health Institute Inc /ID# 249938
🇦🇺Carlton, Victoria, Australia
Sinclair Dermatology - Melbourne /ID# 249937
🇦🇺East Melbourne, Victoria, Australia
Fremantle Dermatology /ID# 249941
🇦🇺Fremantle, Western Australia, Australia
Cliniques Universitaires UCL Saint-Luc /ID# 251403
🇧🇪Woluwe-Saint-Lambert, Bruxelles-Capitale, Belgium
Grand Hopital de Charleroi /ID# 251401
🇧🇪Charleroi, Hainaut, Belgium
Universitair Ziekenhuis Leuven /ID# 251399
🇧🇪Leuven, Vlaams-Brabant, Belgium
CHU de Liege /ID# 251400
🇧🇪Liege, Belgium
UMHAT Dr Georgi Stranski EAD /ID# 251268
🇧🇬Pleven, Smolyan, Bulgaria
Diagnostic Consultative Center Aleksandrovska /ID# 251137
🇧🇬Sofiya, Sofia, Bulgaria
DCC Pulmed AD /ID# 251271
🇧🇬Plovdiv, Bulgaria
Ambulatory for Specialized Medical Care for skin and venereal diseases /ID# 251272
🇧🇬Sofia, Bulgaria
Medical center EuroHealth /ID# 251270
🇧🇬Sofia, Bulgaria
Military Medical Academy Multiprofile Hospital /ID# 251187
🇧🇬Sofia, Bulgaria
Diagnostic consultative center Focus-5 /ID# 251269
🇧🇬Sofiya, Bulgaria
Medical Center Euroderma /ID# 251267
🇧🇬Sofiya, Bulgaria
MC Zara-Med EOOD /ID# 251135
🇧🇬Stara Zagora, Bulgaria
Dermatology Research Institute - Blackfoot Trail /ID# 251642
🇨🇦Calgary, Alberta, Canada
Beacon Dermatology Inc /ID# 250336
🇨🇦Calgary, Alberta, Canada
Alberta DermaSurgery Centre /ID# 250217
🇨🇦Edmonton, Alberta, Canada
Dr. Chih-ho Hong Medical Inc. /ID# 251643
🇨🇦Surrey, British Columbia, Canada
Enverus Medical Research /ID# 251645
🇨🇦Surrey, British Columbia, Canada
Wiseman Dermatology Research /ID# 250219
🇨🇦Winnipeg, Manitoba, Canada
Brunswick Dermatology Center /ID# 250220
🇨🇦Fredericton, New Brunswick, Canada
LEADER Research /ID# 251647
🇨🇦Hamilton, Ontario, Canada
DermEffects /ID# 250223
🇨🇦London, Ontario, Canada
Lynde Institute for Dermatology /ID# 251854
🇨🇦Markham, Ontario, Canada
DermEdge Research Inc. /ID# 250216
🇨🇦Mississauga, Ontario, Canada
SKiN Centre for Dermatology /ID# 251853
🇨🇦Peterborough, Ontario, Canada
Toronto Dermatology Centre /ID# 252098
🇨🇦Toronto, Ontario, Canada
Research Toronto /ID# 250222
🇨🇦Toronto, Ontario, Canada
Private Practice - Dr. Kim Papp Clinical Research /ID# 251644
🇨🇦Waterloo, Ontario, Canada
Centre de Recherche dermatologique du Quebec Metropolitain /ID# 250427
🇨🇦Québec, Quebec, Canada
The First Affiliated Hospital Of Fujian Medical University /ID# 249674
🇨🇳Fuzhou, Fujian, China
Dermatology Hospital of Southern Medical University /ID# 250121
🇨🇳Guangzhou, Guangdong, China
Guangzhou First People's Hospital /ID# 249695
🇨🇳Guangzhou, Guangdong, China
The Second Affiliated Hospital of Guangzhou Medical University /ID# 249694
🇨🇳Guangzhou, Guangdong, China
The University of Hong Kong- Shenzhen Hospital /ID# 249436
🇨🇳Shenzhen, Guangdong, China
The Second Xiangya Hospital of Central South University /ID# 249657
🇨🇳Changsha, Guizhou, China
Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 251485
🇨🇳Wuhan, Hubei, China
The First Hospital of China Medical University /ID# 249638
🇨🇳Shenyang, Liaoning, China
Huashan Hospital, Fudan University /ID# 250025
🇨🇳Shanghai, Shanghai, China
Shanghai Skin Disease Hospital /ID# 249392
🇨🇳Shanghai, Shanghai, China
Tianjin Medical University General Hospital /ID# 250246
🇨🇳Tianjin, Tianjin, China
Hangzhou First People's Hospital /ID# 249437
🇨🇳Hangzhou, Zhejiang, China
The second affiliated hospital of Zhejiang University school of medicine /ID# 249655
🇨🇳Hangzhou, Zhejiang, China
Zhejiang Provincial People's Hospital /ID# 249653
🇨🇳Hangzhou, Zhejiang, China
DermaPlus - Poliklinika za dermatologiju i venerologiju /ID# 249591
🇭🇷Zagreb, Grad Zagreb, Croatia
Djecja bolnica Srebrnjak /ID# 249594
🇭🇷Zagreb, Grad Zagreb, Croatia
Klinicki bolnicki centar Zagreb /ID# 249596
🇭🇷Zagreb, Grad Zagreb, Croatia
Klinika za dječje bolesti Zagreb /ID# 249590
🇭🇷Zagreb, Grad Zagreb, Croatia
Klinicki bolnicki centar Rijeka /ID# 249593
🇭🇷Rijeka, Primorsko-goranska Zupanija, Croatia
Klinicki Bolnicki Centar (KBC) Split /ID# 249879
🇭🇷Split, Splitsko-dalmatinska Zupanija, Croatia
Poliklinika Solmed /ID# 252138
🇭🇷Grad Zagreb, Croatia
Bispebjerg and Frederiksberg Hospital /ID# 248902
🇩🇰Copenhagen NV, Hovedstaden, Denmark
Herlev and Gentofte Hospital /ID# 248900
🇩🇰Hellerup, Hovedstaden, Denmark
Aarhus Universitetshospital - Skejby /ID# 248899
🇩🇰Aarhus, Midtjylland, Denmark
Roskilde Sygehus /ID# 248901
🇩🇰Roskilde, Sjælland, Denmark
Hopital Saint Joseph /ID# 251053
🇫🇷Marseille, Bouches-du-Rhone, France
CHU de Nantes, Hotel Dieu -HME /ID# 251347
🇫🇷Nantes, Pays-de-la-Loire, France
HCL - Hopital Lyon Sud /ID# 251343
🇫🇷Pierre Benite CEDEX, Rhone, France
Hôpital Saint-Louis /ID# 251052
🇫🇷Paris, France
Universitaetsklinikum Tuebingen /ID# 249552
🇩🇪Tubingen, Baden-Wuerttemberg, Germany
Dermatologische Gemeinschaftspraxis Mahlow /ID# 250306
🇩🇪Blankenfelde-Mahlow, Brandenburg, Germany
Klinikum Darmstadt /ID# 251391
🇩🇪Darmstadt, Hessen, Germany
Universitaetsklinikum Frankfurt /ID# 249544
🇩🇪Frankfurt am Main, Hessen, Germany
Hôpital Charles-Nicolle /ID# 251055
🇫🇷Rouen, France
CHU Toulouse - Hopital Larrey /ID# 251344
🇫🇷Toulouse, France
Universitaetsklinikum Freiburg /ID# 249555
🇩🇪Freiburg, Baden-Wuerttemberg, Germany
Universitaetsklinik Heidelberg /ID# 251458
🇩🇪Heidelberg, Baden-Wuerttemberg, Germany
Studienzentrum an der Hase GbR Dr. Weyergraf/Dr. Frick/Thomas Heiber /ID# 251392
🇩🇪Bramsche, Niedersachsen, Germany
Universitaetsklinikum Bonn /ID# 250307
🇩🇪Bonn, Nordrhein-Westfalen, Germany
Universitaetsklinikum Muenster /ID# 249404
🇩🇪Muenster, Nordrhein-Westfalen, Germany
Universitaetsmedizin Mainz /ID# 249549
🇩🇪Mainz, Rheinland-Pfalz, Germany
Fachklinik Bad Bentheim /ID# 249545
🇩🇪Bad Bentheim, Saarland, Germany
Universitaetsklinikum Leipzig /ID# 249562
🇩🇪Leipzig, Sachsen, Germany
Universitaetsklinikum Schleswig-Holstein Campus Luebeck /ID# 249560
🇩🇪Lübeck, Schleswig-Holstein, Germany
Hautarztpraxis Dr. Niesmann und Dr. Othlinghaus /ID# 251566
🇩🇪Bochum, Germany
Universitaetsklinikum Carl Gustav Carus an der TU Dresden /ID# 251844
🇩🇪Dresden, Germany
Derma Study Center Friedrichshafen GmbH /ID# 251460
🇩🇪Friedrichshafen, Germany
Universitaetsklinikum Hamburg-Eppendorf /ID# 249547
🇩🇪Hamburg, Germany
Dermatologikum Hamburg /ID# 251390
🇩🇪Hamburg, Germany
Klinikum rechts der Isar /ID# 249548
🇩🇪Munich, Germany
401 GSNA - 401 Army General Hospital /ID# 251843
🇬🇷Athens, Attiki, Greece
General Hospital Andreas Syggros /ID# 251842
🇬🇷Athens, Attiki, Greece
Papageorgiou General Hospital /ID# 251840
🇬🇷Thessaloniki, Evrytania, Greece
Bacs-Kiskun Varmegyei Oktatokorhaz /ID# 249850
🇭🇺Kecskemet, Bacs-Kiskun, Hungary
Debreceni Egyetem-Klinikai Kozpont /ID# 249849
🇭🇺Debrecen, Hajdu-Bihar, Hungary
Gyongyosi Bugat Pal Korhaz /ID# 251367
🇭🇺Gyongyos, Heves, Hungary
Pecsi Tudomanyegyetem Klinikai Kozpont /ID# 250419
🇭🇺Pecs, Nograd, Hungary
Somogy Varmegyei Kaposi Mor Oktato Korhaz /ID# 249848
🇭🇺Kaposvár, Somogy, Hungary
Clinexpert Kft /ID# 249822
🇭🇺Budapest, Hungary
Semmelweis Egyetem /ID# 251368
🇭🇺Budapest, Hungary
UNO Medical Trials /ID# 249820
🇭🇺Budapest, Hungary
DERMA-B Egeszsegugyi es Szolgaltato - Debrecen - Gyepusor Utca /ID# 249819
🇭🇺Debrecen, Hungary
Szegedi Tudományegyetem /ID# 249818
🇭🇺Szeged, Hungary
Allergo-Derm Bakos Kft. /ID# 249821
🇭🇺Szolnok, Hungary
Hadassah Medical Center-Hebrew University /ID# 251576
🇮🇱Jerusalem, Yerushalayim, Israel
Rabin Medical Center /ID# 251578
🇮🇱Haifa, Israel
CAST - Center for Advanced Studies and Technology /ID# 251495
🇮🇹Chieti, L Aquila, Italy
Presidio Ospedaliero San Salvatore /ID# 250127
🇮🇹L'Aquila, L Aquila, Italy
IRCCS Istituto Clinico Humanitas /ID# 251493
🇮🇹Rozzano, Milano, Italy
Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 250125
🇮🇹Rome, Roma, Italy
IRCCS Istituti Fisioterapici Ospitalieri-Istituto Dermatologico San Gallicano /ID# 250558
🇮🇹Rome, Roma, Italy
Policlinico Agostino Gemelli /ID# 251494
🇮🇹Rome, Roma, Italy
ASST degli Spedali Civili di Brescia /ID# 250129
🇮🇹Brescia, Italy
Ospedale Piero Palagi /ID# 250206
🇮🇹Florence, Italy
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico /ID# 250123
🇮🇹Milano, Italy
Azienda Ospedaliero-Universitaria di Modena /ID# 250128
🇮🇹Modena, Italy
Azienda Ospedaliera di Perugia - Ospedale S. Maria della Misericordia /ID# 251572
🇮🇹Perugia, Italy
Azienda Ospedaliero Universitaria Pisana /ID# 250124
🇮🇹Pisa, Italy
Medical Corporation Kojinkai Sapporo Skin Clinic /ID# 252549
🇯🇵Sapporo-shi, Hokkaido, Japan
Medical corporation Kojunkai Kosugi Dermatology Clinic /ID# 252554
🇯🇵Kawasaki-shi, Kanagawa, Japan
National Hospital Organization Sagamihara National Hospital /ID# 254518
🇯🇵Sagamihara-shi, Kanagawa, Japan
Queen's Square Medical Center, Dermatology and Allergology /ID# 252551
🇯🇵Yokohama-shi, Kanagawa, Japan
Osaka Habikino Medical Center /ID# 252550
🇯🇵Habikino-shi, Osaka, Japan
Dermatology and Ophthalmology Kume Clinic /ID# 254570
🇯🇵Sakai-shi, Osaka, Japan
Naoko Dermatology Clinic /ID# 254571
🇯🇵Setagaya-ku, Tokyo, Japan
Pusan National University Hospital /ID# 249852
🇰🇷Busan, Busan Gwang Yeogsi, Korea, Republic of
Kyungpook National University Hospital /ID# 249855
🇰🇷중구, Daegu Gwang Yeogsi, Korea, Republic of
Korea University Ansan Hospital /ID# 249814
🇰🇷Ansan-si, Gyeonggido, Korea, Republic of
Soon Chun Hyang University Hospital Bucheon /ID# 249812
🇰🇷Bucheon-si, Gyeonggido, Korea, Republic of
Chungang University Hospital /ID# 251490
🇰🇷Dongjak-gu, Gyeonggido, Korea, Republic of
Ajou University Hospital /ID# 251491
🇰🇷Suwon-si, Gyeonggido, Korea, Republic of
Seoul National University Hospital /ID# 251492
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Konkuk University Medical Center /ID# 249811
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Centro de Dermatologia de Monterrey /ID# 249126
🇲🇽Monterrey, Baja California, Mexico
Eukarya PharmaSite, SC /ID# 249702
🇲🇽Monterrey, Nuevo Leon, Mexico
Cryptex Investigacion Clinica S.A de C.V /ID# 249994
🇲🇽Mexico City, Mexico
Clinical Research Institute SC /ID# 249647
🇲🇽Tlalnepantla de Baz, Mexico
Arké Estudios Clinicos Veracruz /ID# 250147
🇲🇽Veracruz, Mexico
Bravis Ziekenhuis /ID# 251395
🇳🇱Bergen op Zoom, Noord-Brabant, Netherlands
Amsterdam UMC, locatie AMC /ID# 251397
🇳🇱Amsterdam, Noord-Holland, Netherlands
MICS Centrum Medyczne Torun /ID# 251433
🇵🇱Torun, Kujawsko-pomorskie, Poland
Dermed Centrum Medyczne Sp. z o.o /ID# 251429
🇵🇱Lodz, Lodzkie, Poland
Lidia Rajzer - Specjalistyczny Gabinet Dermatologiczno-Kosmetyczny /ID# 252082
🇵🇱Cracow, Malopolskie, Poland
Centrum Nowoczesnych Terapii Dobry Lekarz Sp. z o.o. /ID# 251437
🇵🇱Krakow, Malopolskie, Poland
Royalderm Agnieszka Nawrocka /ID# 251432
🇵🇱Warsaw, Mazowieckie, Poland
Klinika Ambroziak Sp. z o.o. /ID# 249406
🇵🇱Warszawa, Mazowieckie, Poland
Bodyclinic Sp. z o.o. sp.k. /ID# 249599
🇵🇱Warszawa, Mazowieckie, Poland
Zespol Naukowo-Leczniczy Iwolang Dermatologiczne Centrum Uzdrowiskowe Sp. z o.o /ID# 249598
🇵🇱Iwonicz-Zdrój, Podkarpackie, Poland
INTER CLINIC Piotr Adrian Klimiuk /ID# 251430
🇵🇱Bialystok, Podlaskie, Poland
Centrum Badan Klinicznych PI-House sp. z o.o. /ID# 251431
🇵🇱Gdansk, Pomorskie, Poland
Centrum Kliniczno-Badawcze J.Brzezicki, B. Gornikiewicz-Brzezicka Lekarze Spolka /ID# 251438
🇵🇱Elblag, Warminsko-mazurskie, Poland
Solumed Centrum Medyczne /ID# 249641
🇵🇱Poznan, Wielkopolskie, Poland
Centrum Medyczne ALL-MED Badania Kliniczne /ID# 249630
🇵🇱Cracow, Poland
Centro Hospitalar Do Alto Ave - Hospital Senhora Da Oliveira /ID# 249196
🇵🇹Guimarães, Braga, Portugal
Hospital CUF Descobertas /ID# 249193
🇵🇹Lisboa, Regiao Autonoma Da Madeira, Portugal
Centro Hospitalar Universitario do Porto, EPE - Hospital Santo Antonio /ID# 249191
🇵🇹Porto, Regiao Autonoma Da Madeira, Portugal
Hospital Garcia de Orta /ID# 251455
🇵🇹Almada, Setubal, Portugal
2CA-Braga, Hospital de Braga /ID# 250480
🇵🇹Braga, Portugal
Unidade Local de Saude da Regiao de Leiria, EPE /ID# 249194
🇵🇹Leiria, Portugal
Centro Hospitalar de Lisboa Central /ID# 249195
🇵🇹Lisbon, Portugal
Unidade Local de Saúde de Matosinhos, EPE /ID# 249197
🇵🇹Matosinhos, Portugal
Centro Hospitalar Universitario de Sao Joao, EPE /ID# 249192
🇵🇹Porto, Portugal
Dr. Samuel Sanchez PSC /ID# 250389
🇵🇷Caguas, Puerto Rico
Alma M. Cruz Santana, MD-Private practice /ID# 250393
🇵🇷Carolina, Puerto Rico
Clinical Research Puerto Rico /ID# 250394
🇵🇷San Juan, Puerto Rico
GCM Medical Group PSC /ID# 250391
🇵🇷San Juan, Puerto Rico
Bio Terra Med SRL /ID# 249624
🇷🇴Bucharest, Bucuresti, Romania
Private Practice - Dr. Orasan Remus /ID# 249625
🇷🇴Cluj Napoca, Cluj, Romania
Derma therapy spol /ID# 249783
🇸🇰Bratislava, Bratislavsky Kraj, Slovakia
Poliklinika Bezrucova (Cliniq s.r.o.) /ID# 249746
🇸🇰Bratislava, Slovakia
BeneDerma s.r.o. /ID# 251791
🇸🇰Bratislava, Slovakia
University of Pretoria /ID# 250208
🇿🇦Pretoria, Gauteng, South Africa
About Allergy /ID# 249697
🇿🇦Pretoria, Gauteng, South Africa
Highway Medical Centre /ID# 250103
🇿🇦Durban, Kwazulu-Natal, South Africa
Spoke Research Inc /ID# 250091
🇿🇦CAPE TOWN Milnerton, Western Cape, South Africa
Allergy & Immunology (AIU) /ID# 249619
🇿🇦Cape Town, Western Cape, South Africa
Hospital Universitario Germans Trias i Pujol /ID# 251523
🇪🇸Badalona, Barcelona, Spain
Hospital Sant Joan de Deu /ID# 249602
🇪🇸Esplugues de Llobregat, Barcelona, Spain
Hospital Universitario Basurto /ID# 249784
🇪🇸Bilbao, Vizcaya, Spain
Hospital General Universitario de Alicante Doctor Balmis /ID# 251517
🇪🇸Alicante, Spain
Hospital Universitario Virgen de las Nieves /ID# 249785
🇪🇸Granada, Spain
Hospital Universitario La Paz /ID# 251518
🇪🇸Madrid, Spain
Hospital Universitario Virgen Macarena /ID# 249603
🇪🇸Sevilla, Spain
Hospital Universitario y Politecnico La Fe /ID# 251524
🇪🇸Valencia, Spain
Skane University hospital /ID# 250332
🇸🇪Malmo, Skane Lan, Sweden
Karolinska University Hospital Solna /ID# 250328
🇸🇪Solna, Stockholms Lan, Sweden
Norrlands University hospital /ID# 250329
🇸🇪Umea, Vasterbottens Lan, Sweden
Malarsjukhuset /ID# 251908
🇸🇪Eskilstuna, Sweden
Kantonsspital St. Gallen /ID# 250606
🇨🇭St. Gallen, Sankt Gallen, Switzerland
Inselspital, Universitaetsspital Bern /ID# 250577
🇨🇭Bern, Switzerland
Kaohsiung Chang Gung Memorial Hospital /ID# 249260
🇨🇳Kaohsiung City, Kaohsiung, Taiwan
Taichung Veterans General Hospital /ID# 249261
🇨🇳Taichung, Keelung, Taiwan
National Taiwan University Hospital /ID# 249258
🇨🇳Taipei City, Taipei, Taiwan
National Taiwan University Hospital - Hsinchu branch /ID# 249265
🇨🇳Hsinchu City, Taiwan
Taipei Medical University Shuang Ho Hospital /ID# 249256
🇨🇳New Taipei City, Taiwan
Mackay Memorial Hospital /ID# 249259
🇨🇳Taipei City, Taiwan
Taipei Veterans General Hosp /ID# 249263
🇨🇳Taipei, Taiwan
Taipei Municipal Wan Fang Hospital /ID# 251500
🇨🇳Taipei, Taiwan
Linkou Chang Gung Memorial Hospital /ID# 249257
🇨🇳Taoyuan City, Taiwan
Gaziantep Universitesi /ID# 249868
🇹🇷Gaziantep, Adana, Turkey
Ankara City Hospital /ID# 249870
🇹🇷Ankara, Turkey
Akdeniz Universitesi Tip Fakul /ID# 249866
🇹🇷Antalya, Turkey
Uludag University Medical Faculty /ID# 249864
🇹🇷Bursa, Turkey
Erciyes University Medical Faculty /ID# 249863
🇹🇷Kayseri, Turkey
Ondokuz Mayis Universitesi /ID# 249865
🇹🇷Samsun, Turkey