Clinical Profile of Patients With Pulmonary Hypertension Due to Lung Diseases ( Single Center Experience)
- Conditions
- Pulmonary Hypertension
- Registration Number
- NCT02774928
- Lead Sponsor
- Cairo University
- Brief Summary
Development of pulmonary hypertension (PH) in chronic lung diseases has both functional and prognostic implications .
PH in Lung diseases is usually mild to moderate with preserved cardiac output, and evolves slowly alongside the progression of lung disease and hypoxemia .
However, a minority of patients develop severe PH with elevations in pulmonary artery pressure that have been described as ''out of proportion'' to the underlying disease .
The aim of this study is to compare the characteristics and outcomes of consecutive patients with PH-due to lung diseases diagnosed at our specialist referral center over a 1-year period.
- Detailed Description
Development of pulmonary hypertension (PH) in chronic lung diseases has both functional and prognostic implications .
PH in Lung diseases is usually mild to moderate with preserved cardiac output, and evolves slowly alongside the progression of lung disease and hypoxemia .
However, a minority of patients develop severe PH with elevations in pulmonary artery pressure that have been described as ''out of proportion'' to the underlying disease .
Hypotheses for the etiology of this phenotype include greater susceptibility to alveolar hypoxia and/or tobacco smoke , destruction of the capillary vascular bed , inflammatory factors initiating remodeling of the pulmonary vascular bed or the coexistence of idiopathic pulmonary arterial hypertension (IPAH) in patients with lung disease .
Severe PH-lung disease has been arbitrarily defined by a resting mean pulmonary artery pressure (PAP) ≥35 mmHg by RHC . The high and increasing prevalence of chronic lung diseases and the substantial consequences of developing severe PH have generated increasing interest in PH-lung diseases.
Pulmonary vascular research unit at Chest department at Kasr-Alani school of Medicine delivers regional, adult PH service to a population with a chronic lung disease.
The aim of this study is to compare the characteristics and outcomes of consecutive patients with PH-due to lung diseases diagnosed at our specialist referral center over a 1-year period.
Patients diagnosed as chronic lung diseases( COPD,ILD,OSA,Sarcoidosis) will be recruited from out-patient's clinics \& inpatients wards of Internal medicine \& Chest departments, Kasr Al-ainy hospital (from June 2016 to May 2015) A written informed consent matching with Helsinki declaration will be taken from all patients.
2.2 Study methods:
All the enrolled patients will go through the following basically:
1. Detailed standard Demographic \& clinical parameters.
2. Assessment of exercise tolerance (6 MWD \& WHO functional capacity)
3. Assessment of pulmonary function by PFTs.
4. ECG: (Right ventricular strain,Right axis deviation,Right bundle branch block,\& Left side changes 0
5. Echocardiographic evaluation for PAH: ( Right atrial area ,Right ventricular area ,Tricuspid regurgitant jet velocity (TR) ,Tricuspid annular plane systolic excursion)
6. Radiography: including chest X-ray, HRCT chest, V/Q scan\& CT angiography if needed
10. RT sided heart catheterization:
* mPAP
* PCWP
* PVR
* CARDIAC INDEX 11. Statistical analysis: ........
The subjects will be classified according to RHC into either
* Non PAH groups mPAP ≤ 21mmHG
* PAH mPAP≥ 25 mmHG:
* Severe PH-lung diseases mPAP ≥ 35 mmgh
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 150
- COPD diagnosed according to Gold 2015
- Interstial lung diseases
- Obstructive Sleep Apnea
- sarcoidosis
- Bronchogenic carcinoma
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method prevalence of PH 1 year
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Kasr Alaini
🇪🇬Cairo, Egypt