Retrospective Study About 17 Cases of Child With Bacterial Meningitis Coupled With Cerebral Vasculitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 17
- 试验地点
- 1
- 主要终点
- Found a difference demographic data
研究概览
简要总结
Purulent meningitis are life-threatening diseases in childhood. Cerebral vasculitis have been described in bacterial meningitis, but poor is known about their physiology and their impact on outcome.
The investigators decide to realize a retrospective mono-centric study carried out at Montpellier university hospital which looks back at a 7-year study(2009-2016).
The Investigators selected purulent meningitis cases based on the bacteriological data provided by the HDB (hospital data base). The Investigators divides in two groups : Group A if patients present a cerebral vasculitis ( radiologic diagnostic by RMI or tomodensitometry), in all, cases the diagnosis of vasculitis was confirmed by a radiologist specialised in neuropaediatrics by a second reading;Group B purulent meningitis with a cerebral vasculitis imaging.
Tuberculous meningitis, meningitis in CSF shunt, and in patients having chemotherapy were excluded.
The investigators report clinical and biological finding, inflammatory marker at the onset. The Investigators register also the clinical evolution and sequelae
详细描述
Meningitis steel are a cause of death in childhood. Cerebral complication are often responsable of poor prognosis. One of these complication vasculitis is steel not weel understood. There are only few study about it on children.
It is a retrospective study about 17 cases of chil which bacterial meningitis coupled wiethe cerebral vasculitis, the Investigators will describe epidemiology, bacteriology, evolution and corticosteroid treatment in this patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 1 Day 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •bacterial meningitis with LCR confirmation
- •Exclusion criteria:
- •tuberculous meningitis, immunosuppressor treatment, material like DVP
排除标准
- 未提供
结局指标
主要结局
Found a difference demographic data
时间窗: 1 day
Found a difference demographic data between population A and B (gender)
Found a difference Inflammatory parkers
时间窗: 1 day
Found a difference Inflammatory parkers between population A and B
Found a difference Clinical manifestation
时间窗: 1 day
Found a difference Clinical manifestation between population A and B
Found a difference Infectious agent
时间窗: 1 day
Found a difference Infectious agent between population A and B
次要结局
- In the A group, studying the relationship between prescription of steroids pulse and final outcome and presence of sequelae.(1 day)
- Found a difference in the evolution of the diseases between group A and B(1 day)