Use of Dexmedetomidine in attenuating the stress response to laryngoscopy and and intubation in patients undergoing mitral valve replacement for severe mitral stenosis.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- 1) Haemodynamic response at 1,3,5 and 10 minutes after endotracheal intubation.
研究概览
简要总结
Dexmedetomidine, an alpha 2 receptor agonist has the ability to blunt the response to any noxious stimuli providing hemodynamic instability. Literature regarding its use in patients with mitral stenosis with the aim to control the heart rate is scarce, hence we aimed to use dexmedetomidine as an adjunct to anesthetic induction and to study the effect of intravenous bolus of dexmedetomidine on heart rate and blood pressure during induction of anesthesia in patients with severe MS undergoing mitral valve replacement.
Objectives of the study are
-
To compare the effect of fentanyl and dexmedetomidine anesthetic induction with fentanyl and thiopentone induction technique on heart rate and blood pressure in such patients
-
To compare cumulative analgesic requirement during surgery and other adverse effects of drug
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •undergoing mitral valve replacement for severe mitral stenosis (Mitral valve area < 1cm2) with or without associated mitral regurgitation.
排除标准
- •Associated other valvular lesions Coexisting hepatic, renal or severe respiratory dysfunction Coexisting coronary artery disease Ejection fraction < 45% Obesity (BMI> 30) Severe systemic disorder (uncontrolled hypertension, insulin dependent DM) Conduction abnormalities.
- •AV block Preoperative use of alpha 2 receptor agonists Intubation attempts lasting > 20 sec.
结局指标
主要结局
1) Haemodynamic response at 1,3,5 and 10 minutes after endotracheal intubation.
时间窗: 1) 1,3,5 and 10 minutes after endotracheal intubation.
次要结局
- Total analgesic consumption during surgery and any other adverse effect of drug(Throughout procedure(beginning till end))