Hemodynamic stability during laryngoscopy and intubation with the use of Dexmedetomidine in severe mitral stenosis patients, posted for mitral valve replacement.

Not yet recruiting

• Conditions: Rheumatic mitral stenosis,

• Registration Number: CTRI/2019/12/022550
• Lead Sponsor: GB Pant Hospital

Brief Summary

Dexmedetomidine, an alpha 2 receptor agonist has the ability to blunt the response to any noxious stimuli providing hemodynamic instability. Literature regarding its use in patients with mitral stenosis with the aim to control the heart rate is scarce, hence we aimed to use dexmedetomidine as an adjunct to anesthetic induction and to study the effect of intravenous bolus of dexmedetomidine on heart rate and blood pressure during induction of anesthesia in patients with severe MS undergoing mitral valve replacement.

Objectives of the study are

1) To compare the effect of fentanyl and dexmedetomidine anesthetic induction with fentanyl and thiopentone induction technique on heart rate and blood pressure in such patients

2) To compare cumulative analgesic requirement during surgery and other adverse effects of drug

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2019-12-27
• Study Start: 2019-12-30

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

undergoing mitral valve replacement for severe mitral stenosis (Mitral valve area < 1cm2) with or without associated mitral regurgitation.

Exclusion Criteria

• Associated other valvular lesions Coexisting hepatic, renal or severe respiratory dysfunction Coexisting coronary artery disease Ejection fraction < 45% Obesity (BMI> 30) Severe systemic disorder (uncontrolled hypertension, insulin dependent DM) Conduction abnormalities.
• AV block Preoperative use of alpha 2 receptor agonists Intubation attempts lasting > 20 sec.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1) Haemodynamic response at 1,3,5 and 10 minutes after endotracheal intubation.	1) 1,3,5 and 10 minutes after endotracheal intubation.

Secondary Outcome Measures

Name	Time	Method
Total analgesic consumption during surgery and any other adverse effect of drug	Throughout procedure(beginning till end)

Trial Locations

Locations (1)

GB Pant Hospital; 🇮🇳 Central, DELHI, India

GB Pant Hospital

🇮🇳Central, DELHI, India

Varun Sharma

Principal investigator

7018546368

shvaroon09@gmail.com