To assess the prolongation of pain relief in children after single dose of intravenous dexmetomidine with the block given in the lowest portion of spine

Active, not recruiting

• Conditions: patients undergoing urethroplasty.

• Registration Number: CTRI/2018/05/013920
• Lead Sponsor: AIIMS

Brief Summary

**Dexmedetomidine** is a short acting selective alpha 2 agonist with sedative anxiolytic and analgesic properties. It has been used as adjunct to general and regional anaesthesia in adults.In adults, there are studies showing analgesic action of  Intravenous dexmedetomidine on epidural block.

After a vast literature search ,we found that there are limited studies on the effect of intravenous dexmedetomidine on caudal analgesia in children. **We hypothesis that intravenous dexmedetomidine might prolong the caudal analgesia in children**. Hence we planned to conduct this study to evaluate the efficacy of intravenous dexmedetomidine for the supplementation of caudal analgesia in children.

the study results is statistically significant increase duration of analgesia with dexmedetomidine group of mean duration  425 minutes  and that of saline group of 300 minutes

Detailed Description

Not available

Study Timeline

• Study Start: 2016-08-08
• Last Update Posted: 2018-09-05

Recruitment & Eligibility

• Status: Closed to Recruitment of Participants
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

ASA I-II Age 2- 8 yrs Undergoing urethroplasty.

Exclusion Criteria

Parental or guardian refusal Hypersensitivity to any local anaesthetic Bleeding diathesis Infection at puncture site Children with uncorrected heart disease Children with heart block or liver impairment Preexisting neurological diseases.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the effect of intravenous dexmedetomidine on caudal analgesia , to compare the time to rescue analgesia.	The duration of analgesia is from the time of caudal injection to the time of FLACC score 4.

Secondary Outcome Measures

Name	Time	Method
To compare the incidence of emergence agitation	To compare the time for discharge based on modified aldrete score.

Trial Locations

Locations (1)

AIIMS , New Delhi; 🇮🇳 Delhi, DELHI, India

AIIMS , New Delhi

🇮🇳Delhi, DELHI, India

Tanya Aysha Edathodu

Principal investigator

9540303301

tanyaedathodu@gmail.com