To know how dexmedetomidine (used as sedative, antihypertensive) used via 2 different routes i.e., inhalation or through intravenous infusion helps in reducing blood pressure and heart rate while inserting a tube in trachea (windpipe) for providing general anaesthesia

Completed

Brief Summary: Dexmedetomidine is a highly selective alpha-2 adrenergic agonist. It is a short-acting sedative, hypnotic, anxiolytic, and analgesic with sympatholytic properties. Its pleiotropic effects have increasingly led to a reduction in anesthetic and analgesic requirements, hence used in the perioperative period. It can be used in various routes like intravenous, intramuscular, nasal, oral, subcutaneous, etc. In our study, we aim to study the efficacy of inhaled dexmedetomidine to intravenous dexmedetomidine in the suppression of intubation response. We hypothesize that dexmedetomidine, when given through the inhalation route, attenuates the intubation response with a better hemodynamic profile with minimal side effects in comparison with intravenous dexmedetomidine.

Recruitment & Eligibility

Inclusion Criteria

Patients undergoing elective surgeries under general anaesthesia 2.
Patients belonging to American Society of Anaesthesiologists Physical Status (ASA-PS) 1 and 2.

Exclusion Criteria

Patient refusal 2.
Patient allergic to study drug 3.
BMI > 30 kg/m2.
Patients with difficulty airway, unanticipated difficult laryngoscopy and intubation ( lasting > 15 seconds or more than 2 attempts at intubation) 5.
Pregnancy and lactation.
Patient on opioids, sedatives, or beta blockers.

Primary Outcome Measures

Name	Time	Method
1. To assess the effect of nebulized and intravenous dexmedetomidine on mean	1. Following laryngoscopy at baseline, every minute for 5 minutes and at 10th minute.
arterial pressure response following laryngoscopy.	1. Following laryngoscopy at baseline, every minute for 5 minutes and at 10th minute.

Secondary Outcome Measures

Name	Time	Method
1. To determine the dose sparing effect of induction dose of propofol.	2. To assess the sedation scores preoperatively, using Modified Ramsay sedation score.

Locations (1): Dr B R Ambedkar medical hospital
🇮🇳
Bangalore, KARNATAKA, India
Dr B R Ambedkar medical hospital
🇮🇳Bangalore, KARNATAKA, India
Reshma B M
Principal investigator
8892019120
lucky3276@gmail.com