The Impact of Cardiometabolic Factors on Coronary Artery and Cardiovascular Diseases: a Prospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 3,000
- 试验地点
- 1
- 主要终点
- Coronary plaque progression
研究概览
简要总结
Systematic metabolic diseases are closely related to prevalence and progression of atherosclerosis. This prospective cohort consecutively enrolls patients with coronary artery disease compliacted with metabolic abnormalities such as diabtetes, prediabetes, obesity, chronic kidney disease and hyperuricemia.
详细描述
CArdioMetabolism and Atherosclerotic PlaqUe progreSsion (CAMPUS) study is a single center, prospective cohort study to investigate the impact of cardiometabolic factors on coronary diseases. This study consecutively enrolls patients with coronary artery diseases complicatied with metabolic abnormalities, including diabetes, prediabetes, obesity, chronic kidney disease and hyperuricemia.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-80 years
- •Established coronary artery disease or metabolic disorders, including:
- •Type 2 diabetes diagnosed by one of the following criteria:
- •HbA1c >/= 6.5% Fasting plasma glucose >/= 7.0 mmol/l (confirmed) 2h plasma glucose value during OGTT >/= 11.1 mmol/l Already receiving glucose-lowering agents
- •Prediabetes
- •Chronic kidney disease
- •Hyperuricemia
- •Dyslipidemia
排除标准
- •Severe liver failure (Child-Pugh grade B to C)
- •Severe anemia (hemoglobin < 60g/L)
- •Familial hypercholesterolemia
- •Active malignant tumor
- •Active autoimmune diseases on corticosteroids
- •Acute or chronic infection
- •Life expectancy < 1 year
结局指标
主要结局
Coronary plaque progression
时间窗: 12 months
Assessed by coronary angiography and QCA
Coronary lesion severity
时间窗: 12 months
Assessed by coronary angiography and QCA
次要结局
- Coronary plaque characteristics(12 months)
- Cardiovascular events(up to 5 years)