The Impact of Cardiometabolic Factors on Coronary Artery and Cardiovascular Diseases: a Prospective Cohort Study
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Coronary Artery Disease
- Sponsor
- Ruijin Hospital
- Enrollment
- 3000
- Locations
- 1
- Primary Endpoint
- Coronary plaque progression
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
Systematic metabolic diseases are closely related to prevalence and progression of atherosclerosis. This prospective cohort consecutively enrolls patients with coronary artery disease compliacted with metabolic abnormalities such as diabtetes, prediabetes, obesity, chronic kidney disease and hyperuricemia.
Detailed Description
CArdioMetabolism and Atherosclerotic PlaqUe progreSsion (CAMPUS) study is a single center, prospective cohort study to investigate the impact of cardiometabolic factors on coronary diseases. This study consecutively enrolls patients with coronary artery diseases complicatied with metabolic abnormalities, including diabetes, prediabetes, obesity, chronic kidney disease and hyperuricemia.
Investigators
RUIYAN ZHANG
Professor
Ruijin Hospital
Eligibility Criteria
Inclusion Criteria
- •Age 18-80 years
- •Established coronary artery disease or metabolic disorders, including:
- •Type 2 diabetes diagnosed by one of the following criteria:
- •HbA1c \>/= 6.5% Fasting plasma glucose \>/= 7.0 mmol/l (confirmed) 2h plasma glucose value during OGTT \>/= 11.1 mmol/l Already receiving glucose-lowering agents
- •Prediabetes
- •Chronic kidney disease
- •Hyperuricemia
- •Dyslipidemia
Exclusion Criteria
- •Severe liver failure (Child-Pugh grade B to C)
- •Severe anemia (hemoglobin \< 60g/L)
- •Familial hypercholesterolemia
- •Active malignant tumor
- •Active autoimmune diseases on corticosteroids
- •Acute or chronic infection
- •Life expectancy \< 1 year
Outcomes
Primary Outcomes
Coronary plaque progression
Time Frame: 12 months
Assessed by coronary angiography and QCA
Coronary lesion severity
Time Frame: 12 months
Assessed by coronary angiography and QCA
Secondary Outcomes
- Coronary plaque characteristics(12 months)
- Cardiovascular events(up to 5 years)