Have a Good Grasp of the Worldthe World

Not Applicable

Completed

• Conditions: Schizophrenic Disorders
• Interventions: Other: cognitive tasks; Other: cognitive tasks + PANSS+ IQ

• Registration Number: NCT02655172
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

Brief Summary: In schizophrenia, dislocation of psychic functions involving a loss of contact with reality is frequently found. A fragmentation of motor and sensory perceptions could be held responsible. However, automatic integration between perception and action is the necessary condition to be in "relationship with the world." Affordance is the experimental link between object perception and potentially associated actions (Gibson, 1977, 1979) explored by Stimulus Response Compatibility (SRC) paradigm. With Tucker \& Ellis sensory motor compatibility task (1998), with a modified response device (responses given with grasp), we study the impact of motor activation on these affordance effects. In this study, a group of controls will also be included in order to understand, as precisely as possible, the mechanisms involved (i.e., interference between the perception of the object and the response gesture).

Detailed Description

Schizophrenic patients will perform: Alert TEA, (Zimmermann and Fimm, 2005), Edinburgh laterality questionnaire (Oldfield, 1971), IQ test (IQ: PM38, Raven, 1960), and the PANSS (Positive and Negative Syndrome Scale, Kay et al., 1987). Controls will only perform the laterality questionnaire. Then all will perform the affordance task, in which photographs of 20 objects of everyday life, typically graspable with one hand, are presented in 4 orientations. Participants have to respond in a graspable device, as quickly as possible, if the object is presented upright or inverted.

Study Timeline

• Study First Submitted: 2016-01-12
• Study First Submitted QC: 2016-01-12
• Study First Posted: 2016-01-13
• Study Start: 2016-05-24
• Primary Completion: 2019-04-03
• Study Completion: 2019-04-03
• Status Verified: 2019-09
• Last Update Submitted: 2019-09-05
• Last Update Posted: 2019-09-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 41

Inclusion Criteria

• For patients:

  • a DSM-IV diagnosis of schizophrenia (men or women),
  • no change in antipsychotic medication and clinical status within four weeks prior to the study

• For patients and control group • Age ≥ 18 years et ≤ 55 years

Exclusion Criteria

• History of head trauma,
• neurological disease with cerebral repercussion or not stabilized serious physical illness;
• psychotropic medication
• disorders related to the use of a psychoactive substance (abuse, dependence or withdrawal);

Exclusion Criteria:

• For patients:

  • IQ < 70

• For patients and control group

  • History of head trauma,
  • neurological disease with cerebral repercussion or not stabilized serious physical illness;
  • psychotropic medication
  • disorders related to the use of a psychoactive substance (abuse, dependence or withdrawal);

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	cognitive tasks	healthy patients who will perform cognitive tasks
Patients	cognitive tasks + PANSS+ IQ	patients suffering schizophrenic disorders and who will perform cognitive tasks + PANSS+ IQ

Primary Outcome Measures

Name	Time	Method
response time	day 1	The gain provided by the compatible vs incompatible conditions (ms response time)

Trial Locations

Locations (1)

Chu Saint-Etienne; 🇫🇷 Saint-etienne, France