ITE-PD: Unraveling the Neural Mechanisms underlying Compensation Strategies for Gait Impairments in Parkinson*s Disease: a Transnational, Multimodal Approach

Recruiting

Conditions: Gait impairment in Parkinsons disease
10028037

Registration Number: NL-OMON51823

Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 104

Inclusion Criteria

- Men and women of age > 18 years with idiopathic Parkinson*s disease;
- Presence of disabling gait impairment;
- Written informed consent.

Exclusion Criteria

- Usage of compensation strategies for the past six months;
- Presence of deep brain stimulation (DBS);
- Presence of severe co-morbidity limiting ambulation (e.g. stroke, orthopaedic
problems);
- Inability to walk unaided (with the exception of a customary cane);
- Inability to walk for >3 minutes consecutively;
- Severe auditory impairments, hampering perception of auditory cues;
- Severe cognitive impairments, hampering the ability to comply to the study
protocol.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main parameter is the degree of cortical activation during walking, as<br /><br>measured by ambulatory high-density EEG.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary parameters involve spatiotemporal parameters, including gait speed<br /><br>and stride length. The use of the application by responders will be recorded<br /><br>(expressed in frequency and duration). Responders additionally report the<br /><br>efficacy of cueing in daily life, which is expressed as the self-reported<br /><br>number of times using the strategy and the perceived efficacy using a<br /><br>five-point Likert scale during follow-up. </p><br>