Diffusion-weighted MRI in Juvenile Idiopathic Arthritis

Completed

Conditions: Childhood Arthritis
Juvenile Idiopathic Arthritis
10003816
10023213

Registration Number: NL-OMON47139

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 185

Inclusion Criteria

Clinically suspected JIA with knee involvement / JIA patients with remitting disease and knee involvement.
Scheduled to undergo MRI.
Written informed patients (when >12 years of age) and parental consent.;OR;JIA patients with clinically inactive disease for at least 6 months.
A history of clinical evident arthritis in at least 1 knee.
Scheduled to undergo MRI.
Written informed patients (when >12 years of age) and parental consent.

Exclusion Criteria

Age <8 and *18 years.
A history of intra-articular corticosteroids injection within the last 6 months.
The need for anesthesia during the MRI examination.
General contraindications for MRI (such as renal insufficiency, pregnancy and claustrophobia).
Lack of written informed consent.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The diagnostic accuracy of DWI in the evaluation of disease activity in JIA as<br /><br>compared to contrast-enhanced MRI as the reference standard.<br /><br><br /><br>The accuracy of DWI in detecting joint inflammation as compared to the physical<br /><br>examination in the evaluation of different stages of disease activity in JIA<br /><br>patients.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The correlation between DWI and semi-quantitative scores of synovial<br /><br>hypertrophy using the Juvenile Arthritis MRI Scoring (JAMRIS) system (at<br /><br>baseline and at two-year follow-up).<br /><br>The degree of association between DWI parameters and scores obtained from the<br /><br>physical examination (at baseline and at two-year follow-up).<br /><br>The correlation between DWI parameters and laboratory assessments of<br /><br>inflammatory parameters (at baseline and at two-year follow-up).<br /><br>The value of DWI in predicting the clinical course in 1 year time in JIA<br /><br>patients.<br /><br>The responsiveness to change of DWI parameters. </p><br>