Neural Circuits for Action Perception

Recruiting

• Conditions: Epilepsy

• Registration Number: NCT05507320
• Lead Sponsor: Boston Children's Hospital

Brief Summary

Study the mechanisms underlying action recognition and execution

Detailed Description

Subjects will participate in a task where they have to either

1. Perform a movement

2. Observe an actor performing a movement There are three types of actions including different kinematics and grip types The goal is to compare the neural circuits activated by action execution versus action observation.

Study Timeline

• Study Start: 2021-09-01
• Status Verified: 2022-08
• Study First Submitted: 2022-08-09
• Study First Submitted QC: 2022-08-17
• Last Update Submitted: 2022-08-17
• Study First Posted: 2022-08-18
• Last Update Posted: 2022-08-18
• Primary Completion: 2025-09-01
• Study Completion: 2025-09-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patients with pharmacologically intractable epilepsy

Exclusion Criteria

• Any situation that may put the patient at risk

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Selectivity for kinematics and movement type in neurophysiological responses	Through study completion, an average of 2 years.	Measure intracranial field potentials (in microvolts) in the gamma frequency band through neurophysiological responses comparing neural responses during action perception versus execution.; We will assess selectivity for kinematics for each movement type
Evoked responses by action execution	Through study completion, an average of 2 years.	Measure intracranial field potentials (in microvolts) in the gamma frequency band through neurophysiological responses comparing neural responses during action perception versus execution.; We will quantify responses evoked by action execution
Evoked responses by action observation	Through study completion, an average of 2 years.	Measure intracranial field potentials (in microvolts) in the gamma frequency band through neurophysiological responses comparing neural responses during action perception versus execution.; We will quantify responses evoked by action observation

Trial Locations

Locations (1)

Boston Children's Hospital; 🇺🇸 Boston, Massachusetts, United States