Cognitive monitoring in SCD

Not Applicable

• Conditions: Diseases of the nervous system

• Registration Number: KCT0005254
• Lead Sponsor: The Catholic University of Korea, Uijeongbu St. Mary’s Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 18 August 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1) Elderly aged 60 or older who complained consistent cognitive decline and visited hospital for dementia work-ups
2) Subjects who underwent neuropsychological tests and brain MRIs
3) Normal performance on all domains of neuropsychological tests (at least -1 standard deviation)
4) Clinical dementia rating score 0
5) Subjects who can visit hospital and undergo follow up evaluations during the study period
6) Subjects who agreed with the study process

Exclusion Criteria

1) mild cognitive impairment or dementia
2) Other cerebral lesions which can cause cognitive impairments on brain MRI (hydrocephalus, cerebral hemorrhage, strategic infarction, tumor)
3) Other neurological disorders except Alzheimer's disease such as Huntington's disease, Parkinson's disease, epilepsy
4) Subjects with severe hearing impairment who cannot undergo phone-based cognitive tests

Study & Design

• Study Type: Observational Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Korean version of Mini-Mental State Examination score change during 48 months (range, 0~30)

Secondary Outcome Measures

Name	Time	Method
blood amyloid beta value (range, 0~ );Clinical dementia rating (CDR) sum of boxes score (range, 0~18);Korean version of Mini-Mental State Examination score (range, 0~30);Home-based cognitive test score (range, 0~30)