Cerebral perfusion, measured by Arterial Spin Labeling (ASL) perfusion MRI, in relation to outcome in children and young adults with ischaemic stroke

Completed

• Conditions: ischaemic stroke; stroke; 10007963; 10003216

• Registration Number: NL-OMON31120
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

For patients in the retrospective cohort:
- Children at the age of 7 years - 18 years and adults between 18 and 50 years of age
- Patients can undergo MR imaging on the 3 Tesla MR scanner without the necessity for anaesthesia (children > 6 years of age)
- Patients treated in the UMC Utrecht for arterial ischaemic stroke in the anterior cerebral circulation between January 2000 and August 2007
- Proven non-atherosclerotic arteriopathy at vascular imaging < 3 months after the onset of symptoms
- Informed consent must be given by the patient and/or parents.;For patients in the prospective cohort:
- Children at the age of 1 month - 18 years and adults between 18 and 50 years of age
- Patients are able to undergo MR investigation within 72 hours after the onset of symptoms and after 6 and 12 months
- Arterial ischaemic stroke (AIS) in the anterior cerebral circulation
- The cause of stroke is an underlying non-atherosclerotic arteriopathy
- Informed consent must be given by the patient and/or parents.

Exclusion Criteria

Contra-indications for MRI
(claustrophobia; pacemaker or automatic defibrillator; some mechanical heart valves; swan-ganz catheter; some aneurysm clips; gastrointestinal clips; cochlear implant; metal object in eye; dental prosthesis with magnetic attachment; hip prosthesis and metal hipnails of more than 50 cm; hydrocephalus- or insulinpump; uncovered skin; medicine patch; piercing)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary outcome measure: functional outcome, defined as *good* or *poor*.<br /><br>Standardized outcome measures for stroke will be used (Paediatic Stroke Outcome<br /><br>Measure (PSOM)), modified Rankin Scale (mRS) and Quality of Life outcome<br /><br>scales). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcome measure: recurrent stroke during follow-up</p><br>