The Role of Repetitive Trans Cranial-magnetic Stimulation in Craving Reduction Among Opioid Use Disorder Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 52
- 主要终点
- craving severity
研究概览
简要总结
Repetitive Trans-cranial Magnetic Stimulation (rTMS) is a relatively safe and non-invasive method to modulate neuronal activity; rTMS uses alternating magnetic fields in a certain frequency to induce an electric current in the underlying brain tissue.
Administering high frequency rTMS to the left dorsolateral prefrontal cortex is possible to increase brain activity in the stimulated area and to change brain activity in associated regions that are part of the same neural circuit which may reduce craving.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Participant)
盲法说明
single blind sham-controlled randomized clinical trial
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Age range: 18-45 years old
- •Gender: males
- •Opioid Use disorder according to the DSM-5 (early abstinence starting 1 week up to 1 month).
排除标准
- •Presence of other serious mental illness (e.g.; psychotic disorders, bipolar affective disorder, depression with psychotic features).
- •Patients with any other serious medical illness.
- •Previous treatment with repetitive Trans- cranial magnetic stimulation.
- •Patients with contraindications to rTMS as cardiac patient with pacemaker.
结局指标
主要结局
craving severity
时间窗: 6 weeks
measure severity of drug craving using craving severity scale, the scale is called brief substance craving scale. a higher outcome is a worse result
heroin craving
时间窗: 6 weeks
using the heroin craving questionnaire, a higher score indicates a worse outcome
次要结局
未报告次要终点
研究者
Noha Ahmed Saad
assistant lecturer of Neuropsychiatry
Ain Shams University