The Role of Repetitive Trans Cranial-magnetic Stimulation in Craving Reduction Among Opioid Use Disorder Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Substance Use Disorders
- Sponsor
- Ain Shams University
- Enrollment
- 52
- Primary Endpoint
- craving severity
- Last Updated
- 4 years ago
Overview
Brief Summary
Repetitive Trans-cranial Magnetic Stimulation (rTMS) is a relatively safe and non-invasive method to modulate neuronal activity; rTMS uses alternating magnetic fields in a certain frequency to induce an electric current in the underlying brain tissue.
Administering high frequency rTMS to the left dorsolateral prefrontal cortex is possible to increase brain activity in the stimulated area and to change brain activity in associated regions that are part of the same neural circuit which may reduce craving.
Investigators
Noha Ahmed Saad
assistant lecturer of Neuropsychiatry
Ain Shams University
Eligibility Criteria
Inclusion Criteria
- •Age range: 18-45 years old
- •Gender: males
- •Opioid Use disorder according to the DSM-5 (early abstinence starting 1 week up to 1 month).
Exclusion Criteria
- •Presence of other serious mental illness (e.g.; psychotic disorders, bipolar affective disorder, depression with psychotic features).
- •Patients with any other serious medical illness.
- •Previous treatment with repetitive Trans- cranial magnetic stimulation.
- •Patients with contraindications to rTMS as cardiac patient with pacemaker.
Outcomes
Primary Outcomes
craving severity
Time Frame: 6 weeks
measure severity of drug craving using craving severity scale, the scale is called brief substance craving scale. a higher outcome is a worse result
heroin craving
Time Frame: 6 weeks
using the heroin craving questionnaire, a higher score indicates a worse outcome