the Role of Repetitive Trans Cranial-magnetic Stimulation in Craving Reduction Among Opioid Use Disorder Patients
Not Applicable
- Conditions
- Substance Use Disorders
- Interventions
- Device: repetitive trans magnetic stimulation
- Registration Number
- NCT04691167
- Lead Sponsor
- Ain Shams University
- Brief Summary
Repetitive Trans-cranial Magnetic Stimulation (rTMS) is a relatively safe and non-invasive method to modulate neuronal activity; rTMS uses alternating magnetic fields in a certain frequency to induce an electric current in the underlying brain tissue.
Administering high frequency rTMS to the left dorsolateral prefrontal cortex is possible to increase brain activity in the stimulated area and to change brain activity in associated regions that are part of the same neural circuit which may reduce craving.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Male
- Target Recruitment
- 52
Inclusion Criteria
- Age range: 18-45 years old
- Gender: males
- Opioid Use disorder according to the DSM-5 (early abstinence starting 1 week up to 1 month).
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Exclusion Criteria
- Presence of other serious mental illness (e.g.; psychotic disorders, bipolar affective disorder, depression with psychotic features).
- Patients with any other serious medical illness.
- Previous treatment with repetitive Trans- cranial magnetic stimulation.
- Patients with contraindications to rTMS as cardiac patient with pacemaker.
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description group 2, sham controlled group repetitive trans magnetic stimulation - group 1, Active intervention group repetitive trans magnetic stimulation -
- Primary Outcome Measures
Name Time Method craving severity 6 weeks measure severity of drug craving using craving severity scale, the scale is called brief substance craving scale. a higher outcome is a worse result
heroin craving 6 weeks using the heroin craving questionnaire, a higher score indicates a worse outcome
- Secondary Outcome Measures
Name Time Method