Transcranial Pulse Stimulation on Motor Cortex

Not Applicable

Completed

• Conditions: Healthy Adults

• Registration Number: NCT06312930
• Lead Sponsor: The Hong Kong Polytechnic University

Brief Summary

Transcranial pulse stimulation (TPS) is a newly developed non-invasive brain stimulation (NIBS) technique from Austria \& Germany with highly promising applicability in neuropsychiatric disorders. Clinical trials have shown a beneficial effect of TPS in patients with Alzheimer\'s disease and depression. However, the mechanism of action of TPS treatment is unknown. There is a lack of controlled studies with sufficient sample size to draw reliable conclusions on the modulatory effect of TPS. The primary motor cortex is a common target when investigating the neuromodulation effect of NIBS techniques. Here, a randomized, cross-over, single-blind, sham-controlled clinical trial is proposed to probe the effects of TPS over the primary motor cortex on modulating motor response and motor behavior.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-03-04
• Study First Submitted QC: 2024-03-08
• Study Start: 2024-03-14
• Study First Posted: 2024-03-15
• Status Verified: 2024-12
• Primary Completion: 2024-12-03
• Study Completion: 2024-12-03
• Last Update Submitted: 2025-06-29
• Last Update Posted: 2025-07-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• Age 18 to 65
• No physical, neurological or psychiatric disorder
• Right-handedness

Exclusion Criteria

• Background with neuroscience
• TPS and TMS contraindications, including metal implants, pregnancy, coagulation disorders, thrombosis, brain tumor, cortisone therapy up to 6 weeks before first stimulation, pacemakers or cochlear implants.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Change in reaction time in Deary-Liewald reaction time task after TPS	Immediately after the completion of the single session TPS, 10 minutes after the single session TPS, 20 minutes after the single session TPS, 30 minutes after the single session TPS, 40 minutes after the single session TPS	Primary clinical outcome measure will be a change in reaction time in Deary-Liewald reaction time task after TPS. Less reaction time is indicative of greater improvement in motor function.
Change in movement time in nine-hole peg test after TPS	Immediately after the completion of the single session TPS, 10 minutes after the single session TPS, 20 minutes after the single session TPS, 30 minutes after the single session TPS, 40 minutes after the single session TPS	Primary clinical outcome measure will be a change in movement time in nine-hole peg test after TPS. Less movement time is indicative of greater improvement in hand dexterity and motor function.

Secondary Outcome Measures

Name	Time	Method
The influence of motor excitability measured by resting motor threshold (RMT) on post-TPS motor performance	30 minutes before TPS session, immediately after the completion of the single session TPS, 10 minutes after the single session TPS, 20 minutes after the single session TPS, 30 minutes after the single session TPS, 40 minutes after the single session TPS	The RMT will be measured before the TPS, which is indicative of the motor excitability. The investigators will explore the correlation between the RMT and post-TPS motor performance measured by the nine-hole peg test; as well as explore correlation between RMT and post-TPS motor performance measured by the Deary-Liewald reaction time task.

Trial Locations

Locations (1)

Georg Kranz, PhD; 🇭🇰 Hong Kong, Hung Hom, Kowloon, Hong Kong