Risk factors and consequences of atrophy of the hippocampal formation in patients with manifest arterial disease: the SMART-Medea study

Completed

• Conditions: cognition; hippocampal atrophy; 10042258; 10003216

• Registration Number: NL-OMON37630
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 420

Inclusion Criteria

All persons still alive who participated in the baseline examination of the SMART-Medea study from 2006 through 2009.

Exclusion Criteria

Contra-indications for MR imaging (metal objects in the body, claustrophobia, pregnancy). Terminally ill or physically unable to come to the UMCU.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Outcome variables for the primary objective are 1a) hippocampal and entorhinal<br /><br>cortex volume at 1.5T MRI, and 1b) cognitive functioning and late-life<br /><br>depression after 7 years of follow-up.<br /><br><br /><br>Outcome variables for the second objective are 2a) cognitive functioning and<br /><br>late-life depression, and 2b) volumes of hippocampal subfields at 7T MRI.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable.</p><br>