Identification of proteins and genes involved in proliferative diabetic retinopathy
Completed
- Conditions
- proliferative diabetic retinopathy. Vessel newgrowth in retina in diabetes10047060
- Registration Number
- NL-OMON39671
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
Patients with proliferative diabetic retinopathy who need a vitrectomy.
Controlgroup: Patients (without diabetes mellitus) with a macular hole, a macular pucker or vitreous floaters who need a vitrectomy
Exclusion Criteria
No informed consent
Age >18 years
Legal incapacity
In the control group:
No informed consent
Age >18 years
Legal incapacity
Diabetes mellitus
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary study parameter is presence of to-be-detremined proteins in the<br /><br>vitreous of patients with PDR compared with healthy persons.<br /><br>Furthermore, using microarray analysis, RNA transcripts will be determined that<br /><br>are increased in patients with PDR compared to non-diabetic patients.</p><br>
- Secondary Outcome Measures
Name Time Method <p>not applicable</p><br>